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The Role of Lung and Gut Microbiota in the Pathology of Asthma

Asthma is a common chronic respiratory disease affecting more than 300 million people worldwide. Clinical features of asthma and its immunological and molecular etiology vary significantly among patients. An understanding of the complexities of asthma has evolved to the point where precision medicin...

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Autores principales: Barcik, Weronika, Boutin, Rozlyn C.T., Sokolowska, Milena, Finlay, B. Brett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128389/
https://www.ncbi.nlm.nih.gov/pubmed/32075727
http://dx.doi.org/10.1016/j.immuni.2020.01.007
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author Barcik, Weronika
Boutin, Rozlyn C.T.
Sokolowska, Milena
Finlay, B. Brett
author_facet Barcik, Weronika
Boutin, Rozlyn C.T.
Sokolowska, Milena
Finlay, B. Brett
author_sort Barcik, Weronika
collection PubMed
description Asthma is a common chronic respiratory disease affecting more than 300 million people worldwide. Clinical features of asthma and its immunological and molecular etiology vary significantly among patients. An understanding of the complexities of asthma has evolved to the point where precision medicine approaches, including microbiome analysis, are being increasingly recognized as an important part of disease management. Lung and gut microbiota play several important roles in the development, regulation, and maintenance of healthy immune responses. Dysbiosis and subsequent dysregulation of microbiota-related immunological processes affect the onset of the disease, its clinical characteristics, and responses to treatment. Bacteria and viruses are the most extensively studied microorganisms relating to asthma pathogenesis, but other microbes, including fungi and even archaea, can potently influence airway inflammation. This review focuses on recently discovered connections between lung and gut microbiota, including bacteria, fungi, viruses, and archaea, and their influence on asthma.
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spelling pubmed-71283892020-04-06 The Role of Lung and Gut Microbiota in the Pathology of Asthma Barcik, Weronika Boutin, Rozlyn C.T. Sokolowska, Milena Finlay, B. Brett Immunity Review Asthma is a common chronic respiratory disease affecting more than 300 million people worldwide. Clinical features of asthma and its immunological and molecular etiology vary significantly among patients. An understanding of the complexities of asthma has evolved to the point where precision medicine approaches, including microbiome analysis, are being increasingly recognized as an important part of disease management. Lung and gut microbiota play several important roles in the development, regulation, and maintenance of healthy immune responses. Dysbiosis and subsequent dysregulation of microbiota-related immunological processes affect the onset of the disease, its clinical characteristics, and responses to treatment. Bacteria and viruses are the most extensively studied microorganisms relating to asthma pathogenesis, but other microbes, including fungi and even archaea, can potently influence airway inflammation. This review focuses on recently discovered connections between lung and gut microbiota, including bacteria, fungi, viruses, and archaea, and their influence on asthma. Published by Elsevier Inc. 2020-02-18 2020-02-18 /pmc/articles/PMC7128389/ /pubmed/32075727 http://dx.doi.org/10.1016/j.immuni.2020.01.007 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Barcik, Weronika
Boutin, Rozlyn C.T.
Sokolowska, Milena
Finlay, B. Brett
The Role of Lung and Gut Microbiota in the Pathology of Asthma
title The Role of Lung and Gut Microbiota in the Pathology of Asthma
title_full The Role of Lung and Gut Microbiota in the Pathology of Asthma
title_fullStr The Role of Lung and Gut Microbiota in the Pathology of Asthma
title_full_unstemmed The Role of Lung and Gut Microbiota in the Pathology of Asthma
title_short The Role of Lung and Gut Microbiota in the Pathology of Asthma
title_sort role of lung and gut microbiota in the pathology of asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128389/
https://www.ncbi.nlm.nih.gov/pubmed/32075727
http://dx.doi.org/10.1016/j.immuni.2020.01.007
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