Methods for the characterization of stress granules in virus infected cells

Stress granules are induced in many different viral infections, and in turn are inhibited by the expression of viral proteins or RNAs. It is therefore evident that these bodies are not compatible with efficient viral replication, but the mechanism by which they act to restrict viral gene expression...

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Detalles Bibliográficos
Autores principales: Panas, Marc D., Kedersha, Nancy, McInerney, Gerald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128402/
https://www.ncbi.nlm.nih.gov/pubmed/25896634
http://dx.doi.org/10.1016/j.ymeth.2015.04.009
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author Panas, Marc D.
Kedersha, Nancy
McInerney, Gerald M.
author_facet Panas, Marc D.
Kedersha, Nancy
McInerney, Gerald M.
author_sort Panas, Marc D.
collection PubMed
description Stress granules are induced in many different viral infections, and in turn are inhibited by the expression of viral proteins or RNAs. It is therefore evident that these bodies are not compatible with efficient viral replication, but the mechanism by which they act to restrict viral gene expression or genome replication is not yet understood. This article discusses a number of methods that can be employed to gain a more complete understanding of the relationship between cellular SGs and viral RNA and protein synthesis in cells infected with diverse viruses.
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spelling pubmed-71284022020-04-08 Methods for the characterization of stress granules in virus infected cells Panas, Marc D. Kedersha, Nancy McInerney, Gerald M. Methods Review Article Stress granules are induced in many different viral infections, and in turn are inhibited by the expression of viral proteins or RNAs. It is therefore evident that these bodies are not compatible with efficient viral replication, but the mechanism by which they act to restrict viral gene expression or genome replication is not yet understood. This article discusses a number of methods that can be employed to gain a more complete understanding of the relationship between cellular SGs and viral RNA and protein synthesis in cells infected with diverse viruses. Elsevier Inc. 2015-11-15 2015-04-18 /pmc/articles/PMC7128402/ /pubmed/25896634 http://dx.doi.org/10.1016/j.ymeth.2015.04.009 Text en Copyright © 2015 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Panas, Marc D.
Kedersha, Nancy
McInerney, Gerald M.
Methods for the characterization of stress granules in virus infected cells
title Methods for the characterization of stress granules in virus infected cells
title_full Methods for the characterization of stress granules in virus infected cells
title_fullStr Methods for the characterization of stress granules in virus infected cells
title_full_unstemmed Methods for the characterization of stress granules in virus infected cells
title_short Methods for the characterization of stress granules in virus infected cells
title_sort methods for the characterization of stress granules in virus infected cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128402/
https://www.ncbi.nlm.nih.gov/pubmed/25896634
http://dx.doi.org/10.1016/j.ymeth.2015.04.009
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