Dynamic modeling of cellular response to DNA damage based on p53 stress response networks

Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfull...

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Detalles Bibliográficos
Autores principales: Qi, Jinpeng, Ding, Yongsheng, Shao, Shihuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128557/
https://www.ncbi.nlm.nih.gov/pubmed/32288404
http://dx.doi.org/10.1016/j.pnsc.2009.03.008
Descripción
Sumario:Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes.

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