Dynamic modeling of cellular response to DNA damage based on p53 stress response networks

Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfull...

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Detalles Bibliográficos
Autores principales: Qi, Jinpeng, Ding, Yongsheng, Shao, Shihuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128557/
https://www.ncbi.nlm.nih.gov/pubmed/32288404
http://dx.doi.org/10.1016/j.pnsc.2009.03.008
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author Qi, Jinpeng
Ding, Yongsheng
Shao, Shihuang
author_facet Qi, Jinpeng
Ding, Yongsheng
Shao, Shihuang
author_sort Qi, Jinpeng
collection PubMed
description Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes.
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spelling pubmed-71285572020-04-08 Dynamic modeling of cellular response to DNA damage based on p53 stress response networks Qi, Jinpeng Ding, Yongsheng Shao, Shihuang Prog. Nat. Sci Article Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes. National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Ltd. 2009-10-10 2009-08-05 /pmc/articles/PMC7128557/ /pubmed/32288404 http://dx.doi.org/10.1016/j.pnsc.2009.03.008 Text en Copyright © 2009 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Qi, Jinpeng
Ding, Yongsheng
Shao, Shihuang
Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title_full Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title_fullStr Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title_full_unstemmed Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title_short Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
title_sort dynamic modeling of cellular response to dna damage based on p53 stress response networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128557/
https://www.ncbi.nlm.nih.gov/pubmed/32288404
http://dx.doi.org/10.1016/j.pnsc.2009.03.008
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