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Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice

Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dos...

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Autores principales: CHEN, Mei-Yu, LI, Hong, LU, Xiao-Xiao, LING, Li-Jun, WENG, Hong-Bo, SUN, Wei, CHEN, Dao-Feng, ZHANG, Yun-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Pharmaceutical University. Published by Elsevier B.V. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128561/
https://www.ncbi.nlm.nih.gov/pubmed/30910055
http://dx.doi.org/10.1016/S1875-5364(19)30021-4
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author CHEN, Mei-Yu
LI, Hong
LU, Xiao-Xiao
LING, Li-Jun
WENG, Hong-Bo
SUN, Wei
CHEN, Dao-Feng
ZHANG, Yun-Yi
author_facet CHEN, Mei-Yu
LI, Hong
LU, Xiao-Xiao
LING, Li-Jun
WENG, Hong-Bo
SUN, Wei
CHEN, Dao-Feng
ZHANG, Yun-Yi
author_sort CHEN, Mei-Yu
collection PubMed
description Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg(−1)(d(−1). H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP.
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spelling pubmed-71285612020-04-08 Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice CHEN, Mei-Yu LI, Hong LU, Xiao-Xiao LING, Li-Jun WENG, Hong-Bo SUN, Wei CHEN, Dao-Feng ZHANG, Yun-Yi Chin J Nat Med Article Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg(−1)(d(−1). H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP. China Pharmaceutical University. Published by Elsevier B.V. 2019-03 2019-03-22 /pmc/articles/PMC7128561/ /pubmed/30910055 http://dx.doi.org/10.1016/S1875-5364(19)30021-4 Text en © 2019 China Pharmaceutical University Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
CHEN, Mei-Yu
LI, Hong
LU, Xiao-Xiao
LING, Li-Jun
WENG, Hong-Bo
SUN, Wei
CHEN, Dao-Feng
ZHANG, Yun-Yi
Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title_full Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title_fullStr Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title_full_unstemmed Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title_short Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
title_sort houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in h1n1 virus infected mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128561/
https://www.ncbi.nlm.nih.gov/pubmed/30910055
http://dx.doi.org/10.1016/S1875-5364(19)30021-4
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