The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein

Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication o...

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Autores principales: Spiegel, Martin, Pichlmair, Andreas, Mühlberger, Elke, Haller, Otto, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128634/
https://www.ncbi.nlm.nih.gov/pubmed/15135736
http://dx.doi.org/10.1016/j.jcv.2003.11.013
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author Spiegel, Martin
Pichlmair, Andreas
Mühlberger, Elke
Haller, Otto
Weber, Friedemann
author_facet Spiegel, Martin
Pichlmair, Andreas
Mühlberger, Elke
Haller, Otto
Weber, Friedemann
author_sort Spiegel, Martin
collection PubMed
description Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV.
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spelling pubmed-71286342020-04-08 The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein Spiegel, Martin Pichlmair, Andreas Mühlberger, Elke Haller, Otto Weber, Friedemann J Clin Virol Article Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV. Elsevier B.V. 2004-07 2004-02-04 /pmc/articles/PMC7128634/ /pubmed/15135736 http://dx.doi.org/10.1016/j.jcv.2003.11.013 Text en Copyright © 2003 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Spiegel, Martin
Pichlmair, Andreas
Mühlberger, Elke
Haller, Otto
Weber, Friedemann
The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title_full The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title_fullStr The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title_full_unstemmed The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title_short The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
title_sort antiviral effect of interferon-beta against sars-coronavirus is not mediated by mxa protein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128634/
https://www.ncbi.nlm.nih.gov/pubmed/15135736
http://dx.doi.org/10.1016/j.jcv.2003.11.013
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