Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?

In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that ha...

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Autor principal: Gracia-Ramos, Abraham Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IMSS. Published by Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128661/
https://www.ncbi.nlm.nih.gov/pubmed/32279908
http://dx.doi.org/10.1016/j.arcmed.2020.03.011
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author Gracia-Ramos, Abraham Edgar
author_facet Gracia-Ramos, Abraham Edgar
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description In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that has been recognized as target to which the virus bind to cells. Although this hypothesis is possible, it may also have other explanations which are discussed.
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spelling pubmed-71286612020-04-08 Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection? Gracia-Ramos, Abraham Edgar Arch Med Res Article In the recent coronavirus disease (COVID-19) outbreak, a higher proportion of patients with severe disease were found in older persons with comorbidities. This observation has been related to the use of drugs that can increase the cellular expression of angiotensin-converting enzyme 2 (ACE2) that has been recognized as target to which the virus bind to cells. Although this hypothesis is possible, it may also have other explanations which are discussed. IMSS. Published by Elsevier Inc. 2020-05 2020-04-04 /pmc/articles/PMC7128661/ /pubmed/32279908 http://dx.doi.org/10.1016/j.arcmed.2020.03.011 Text en © 2020 IMSS. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gracia-Ramos, Abraham Edgar
Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title_full Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title_fullStr Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title_full_unstemmed Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title_short Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
title_sort is the ace2 overexpression a risk factor for covid-19 infection?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128661/
https://www.ncbi.nlm.nih.gov/pubmed/32279908
http://dx.doi.org/10.1016/j.arcmed.2020.03.011
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