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The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange. In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we di...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128675/ https://www.ncbi.nlm.nih.gov/pubmed/32243808 http://dx.doi.org/10.1016/j.stem.2020.03.009 |
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| author | Basil, Maria C. Katzen, Jeremy Engler, Anna E. Guo, Minzhe Herriges, Michael J. Kathiriya, Jaymin J. Windmueller, Rebecca Ysasi, Alexandra B. Zacharias, William J. Chapman, Hal A. Kotton, Darrell N. Rock, Jason R. Snoeck, Hans-Willem Vunjak-Novakovic, Gordana Whitsett, Jeffrey A. Morrisey, Edward E. |
| author_facet | Basil, Maria C. Katzen, Jeremy Engler, Anna E. Guo, Minzhe Herriges, Michael J. Kathiriya, Jaymin J. Windmueller, Rebecca Ysasi, Alexandra B. Zacharias, William J. Chapman, Hal A. Kotton, Darrell N. Rock, Jason R. Snoeck, Hans-Willem Vunjak-Novakovic, Gordana Whitsett, Jeffrey A. Morrisey, Edward E. |
| author_sort | Basil, Maria C. |
| collection | PubMed |
| description | The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange. In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration. We also provide future directions for an improved understanding of the cell biology of the respiratory system, as well as new therapeutic avenues. |
| format | Online Article Text |
| id | pubmed-7128675 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Published by Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71286752020-04-08 The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future Basil, Maria C. Katzen, Jeremy Engler, Anna E. Guo, Minzhe Herriges, Michael J. Kathiriya, Jaymin J. Windmueller, Rebecca Ysasi, Alexandra B. Zacharias, William J. Chapman, Hal A. Kotton, Darrell N. Rock, Jason R. Snoeck, Hans-Willem Vunjak-Novakovic, Gordana Whitsett, Jeffrey A. Morrisey, Edward E. Cell Stem Cell Review The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange. In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration. We also provide future directions for an improved understanding of the cell biology of the respiratory system, as well as new therapeutic avenues. Published by Elsevier Inc. 2020-04-02 2020-04-02 /pmc/articles/PMC7128675/ /pubmed/32243808 http://dx.doi.org/10.1016/j.stem.2020.03.009 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Review Basil, Maria C. Katzen, Jeremy Engler, Anna E. Guo, Minzhe Herriges, Michael J. Kathiriya, Jaymin J. Windmueller, Rebecca Ysasi, Alexandra B. Zacharias, William J. Chapman, Hal A. Kotton, Darrell N. Rock, Jason R. Snoeck, Hans-Willem Vunjak-Novakovic, Gordana Whitsett, Jeffrey A. Morrisey, Edward E. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title | The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title_full | The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title_fullStr | The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title_full_unstemmed | The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title_short | The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future |
| title_sort | cellular and physiological basis for lung repair and regeneration: past, present, and future |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128675/ https://www.ncbi.nlm.nih.gov/pubmed/32243808 http://dx.doi.org/10.1016/j.stem.2020.03.009 |
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