Cargando…
Autoinhibition of Bcr-Abl through Its SH3 Domain
Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil d...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press. Published by Elsevier Inc.
2003
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128750/ https://www.ncbi.nlm.nih.gov/pubmed/12887890 http://dx.doi.org/10.1016/S1097-2765(03)00274-0 |