Nanoscale Particles for Lung Delivery of siRNA

Small interfering RNAs (siRNAs) are potent molecules capable of blocking gene expression after entering cell cytoplasm. Despite their strong efficacy, they need to be carried by nanoscale delivery systems that can protect them against degradation in biological fluids, increase their cellular uptake...

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Detalles Bibliográficos
Autores principales: Nascimento, T.L., Hillaireau, H., Fattal, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128800/
http://dx.doi.org/10.1016/S1773-2247(12)50010-9
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author Nascimento, T.L.
Hillaireau, H.
Fattal, E.
author_facet Nascimento, T.L.
Hillaireau, H.
Fattal, E.
author_sort Nascimento, T.L.
collection PubMed
description Small interfering RNAs (siRNAs) are potent molecules capable of blocking gene expression after entering cell cytoplasm. Despite their strong efficacy, they need to be carried by nanoscale delivery systems that can protect them against degradation in biological fluids, increase their cellular uptake and favor their subcellular distribution. Several studies have highlighted the potential of local pulmonary delivery of siRNAs for the treatment of lung diseases. For this purpose, nanoscale delivery systems were addressed to target passively or actively the target cell. This review discusses the possibilities of approaching lung delivery of nanoscale particles carrying siRNAs.
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spelling pubmed-71288002020-04-08 Nanoscale Particles for Lung Delivery of siRNA Nascimento, T.L. Hillaireau, H. Fattal, E. J Drug Deliv Sci Technol Article Small interfering RNAs (siRNAs) are potent molecules capable of blocking gene expression after entering cell cytoplasm. Despite their strong efficacy, they need to be carried by nanoscale delivery systems that can protect them against degradation in biological fluids, increase their cellular uptake and favor their subcellular distribution. Several studies have highlighted the potential of local pulmonary delivery of siRNAs for the treatment of lung diseases. For this purpose, nanoscale delivery systems were addressed to target passively or actively the target cell. This review discusses the possibilities of approaching lung delivery of nanoscale particles carrying siRNAs. Elsevier B.V. 2012 2014-12-17 /pmc/articles/PMC7128800/ http://dx.doi.org/10.1016/S1773-2247(12)50010-9 Text en Copyright © 2012 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nascimento, T.L.
Hillaireau, H.
Fattal, E.
Nanoscale Particles for Lung Delivery of siRNA
title Nanoscale Particles for Lung Delivery of siRNA
title_full Nanoscale Particles for Lung Delivery of siRNA
title_fullStr Nanoscale Particles for Lung Delivery of siRNA
title_full_unstemmed Nanoscale Particles for Lung Delivery of siRNA
title_short Nanoscale Particles for Lung Delivery of siRNA
title_sort nanoscale particles for lung delivery of sirna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128800/
http://dx.doi.org/10.1016/S1773-2247(12)50010-9
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