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Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex
Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway. Locali...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
1992
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128811/ https://www.ncbi.nlm.nih.gov/pubmed/1457777 http://dx.doi.org/10.1016/1043-4682(92)90020-V |
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author | Saraste, Jaakko Kuismanen, Esa |
author_facet | Saraste, Jaakko Kuismanen, Esa |
author_sort | Saraste, Jaakko |
collection | PubMed |
description | Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway. Localization of resident marker proteins has shown that this compartment consists of both peripheral and central elements. The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface. We propose a model which describes how mobile, endosome-like elements of the pre-Golgi compartment function in the generation of the compositional and functional boundary between the widely distributed ER and the more centrally located Golgi stacks. |
format | Online Article Text |
id | pubmed-7128811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1992 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71288112020-04-08 Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex Saraste, Jaakko Kuismanen, Esa Semin Cell Biol Article Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway. Localization of resident marker proteins has shown that this compartment consists of both peripheral and central elements. The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface. We propose a model which describes how mobile, endosome-like elements of the pre-Golgi compartment function in the generation of the compositional and functional boundary between the widely distributed ER and the more centrally located Golgi stacks. Published by Elsevier Ltd. 1992-10 2004-12-07 /pmc/articles/PMC7128811/ /pubmed/1457777 http://dx.doi.org/10.1016/1043-4682(92)90020-V Text en Copyright © 1992 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Saraste, Jaakko Kuismanen, Esa Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title | Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title_full | Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title_fullStr | Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title_full_unstemmed | Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title_short | Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex |
title_sort | pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the golgi complex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128811/ https://www.ncbi.nlm.nih.gov/pubmed/1457777 http://dx.doi.org/10.1016/1043-4682(92)90020-V |
work_keys_str_mv | AT sarastejaakko pathwaysofproteinsortingandmembranetrafficbetweentheroughendoplasmicreticulumandthegolgicomplex AT kuismanenesa pathwaysofproteinsortingandmembranetrafficbetweentheroughendoplasmicreticulumandthegolgicomplex |