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Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China

OBJECTIVES: This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. METHODS: The clinical records, laboratory findings and radiological assessments included chest X-ray or computed to...

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Autores principales: Li, Xun, Wang, Luwen, Yan, Shaonan, Yang, Fan, Xiang, Longkui, Zhu, Jiling, Shen, Bo, Gong, Zuojiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128884/
https://www.ncbi.nlm.nih.gov/pubmed/32251805
http://dx.doi.org/10.1016/j.ijid.2020.03.053
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author Li, Xun
Wang, Luwen
Yan, Shaonan
Yang, Fan
Xiang, Longkui
Zhu, Jiling
Shen, Bo
Gong, Zuojiong
author_facet Li, Xun
Wang, Luwen
Yan, Shaonan
Yang, Fan
Xiang, Longkui
Zhu, Jiling
Shen, Bo
Gong, Zuojiong
author_sort Li, Xun
collection PubMed
description OBJECTIVES: This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. METHODS: The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. RESULTS: The age and underlying diseases (hypertension, diabetes, etc.) were the most important risk factors for death of COVID-19 pneumonia. Bacterial infections may play an important role in promoting the death of patients. Malnutrition was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-dimer, LDH and lactate levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts. CONCLUSIONS: The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality.
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spelling pubmed-71288842020-04-08 Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China Li, Xun Wang, Luwen Yan, Shaonan Yang, Fan Xiang, Longkui Zhu, Jiling Shen, Bo Gong, Zuojiong Int J Infect Dis Article OBJECTIVES: This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. METHODS: The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. RESULTS: The age and underlying diseases (hypertension, diabetes, etc.) were the most important risk factors for death of COVID-19 pneumonia. Bacterial infections may play an important role in promoting the death of patients. Malnutrition was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-dimer, LDH and lactate levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts. CONCLUSIONS: The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-05 2020-04-03 /pmc/articles/PMC7128884/ /pubmed/32251805 http://dx.doi.org/10.1016/j.ijid.2020.03.053 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Xun
Wang, Luwen
Yan, Shaonan
Yang, Fan
Xiang, Longkui
Zhu, Jiling
Shen, Bo
Gong, Zuojiong
Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title_full Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title_fullStr Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title_full_unstemmed Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title_short Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China
title_sort clinical characteristics of 25 death cases with covid-19: a retrospective review of medical records in a single medical center, wuhan, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128884/
https://www.ncbi.nlm.nih.gov/pubmed/32251805
http://dx.doi.org/10.1016/j.ijid.2020.03.053
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