Rapid viral quasispecies evolution: implications for vaccine and drug strategies

High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probabil...

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Detalles Bibliográficos
Autores principales: Novella, Isabel S., Domingo, Esteban, Holland, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1995
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128888/
https://www.ncbi.nlm.nih.gov/pubmed/17607887
http://dx.doi.org/10.1016/S1357-4310(95)91551-6
Descripción
Sumario:High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.

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