Rapid viral quasispecies evolution: implications for vaccine and drug strategies

High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probabil...

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Detalles Bibliográficos
Autores principales: Novella, Isabel S., Domingo, Esteban, Holland, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1995
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128888/
https://www.ncbi.nlm.nih.gov/pubmed/17607887
http://dx.doi.org/10.1016/S1357-4310(95)91551-6
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author Novella, Isabel S.
Domingo, Esteban
Holland, John J.
author_facet Novella, Isabel S.
Domingo, Esteban
Holland, John J.
author_sort Novella, Isabel S.
collection PubMed
description High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.
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spelling pubmed-71288882020-04-08 Rapid viral quasispecies evolution: implications for vaccine and drug strategies Novella, Isabel S. Domingo, Esteban Holland, John J. Mol Med Today Review High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising. Published by Elsevier Ltd. 1995-08 2004-11-02 /pmc/articles/PMC7128888/ /pubmed/17607887 http://dx.doi.org/10.1016/S1357-4310(95)91551-6 Text en Copyright © 1995 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Novella, Isabel S.
Domingo, Esteban
Holland, John J.
Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title_full Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title_fullStr Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title_full_unstemmed Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title_short Rapid viral quasispecies evolution: implications for vaccine and drug strategies
title_sort rapid viral quasispecies evolution: implications for vaccine and drug strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128888/
https://www.ncbi.nlm.nih.gov/pubmed/17607887
http://dx.doi.org/10.1016/S1357-4310(95)91551-6
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