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Rapid viral quasispecies evolution: implications for vaccine and drug strategies
High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probabil...
Autores principales: | Novella, Isabel S., Domingo, Esteban, Holland, John J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128888/ https://www.ncbi.nlm.nih.gov/pubmed/17607887 http://dx.doi.org/10.1016/S1357-4310(95)91551-6 |
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