Deubiquitinases and cancer: A snapshot

Ubiquitination is the vital system for controlling protein degradation and regulation of basic cellular processes. Deubiquitinases (DUBs) are emerging as an important regulator of several pathways related to cancer and other diseases. Their ability to detach ubiquitin from the target substrate and r...

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Detalles Bibliográficos
Autores principales: Singh, Nishant, Singh, Anuradha Bharara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ireland Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128910/
https://www.ncbi.nlm.nih.gov/pubmed/27211605
http://dx.doi.org/10.1016/j.critrevonc.2016.04.018
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author Singh, Nishant
Singh, Anuradha Bharara
author_facet Singh, Nishant
Singh, Anuradha Bharara
author_sort Singh, Nishant
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description Ubiquitination is the vital system for controlling protein degradation and regulation of basic cellular processes. Deubiquitinases (DUBs) are emerging as an important regulator of several pathways related to cancer and other diseases. Their ability to detach ubiquitin from the target substrate and regulation of signaling makes it potential target to treat cancer and other fatal diseases. In the current review, we are trying to summarize deubiquitination, and their role in cancer and potential small molecules DUBs inhibitors which can be used as drugs for cancer treatment.
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spelling pubmed-71289102020-04-08 Deubiquitinases and cancer: A snapshot Singh, Nishant Singh, Anuradha Bharara Crit Rev Oncol Hematol Article Ubiquitination is the vital system for controlling protein degradation and regulation of basic cellular processes. Deubiquitinases (DUBs) are emerging as an important regulator of several pathways related to cancer and other diseases. Their ability to detach ubiquitin from the target substrate and regulation of signaling makes it potential target to treat cancer and other fatal diseases. In the current review, we are trying to summarize deubiquitination, and their role in cancer and potential small molecules DUBs inhibitors which can be used as drugs for cancer treatment. Elsevier Ireland Ltd. 2016-07 2016-05-06 /pmc/articles/PMC7128910/ /pubmed/27211605 http://dx.doi.org/10.1016/j.critrevonc.2016.04.018 Text en © 2016 Elsevier Ireland Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Singh, Nishant
Singh, Anuradha Bharara
Deubiquitinases and cancer: A snapshot
title Deubiquitinases and cancer: A snapshot
title_full Deubiquitinases and cancer: A snapshot
title_fullStr Deubiquitinases and cancer: A snapshot
title_full_unstemmed Deubiquitinases and cancer: A snapshot
title_short Deubiquitinases and cancer: A snapshot
title_sort deubiquitinases and cancer: a snapshot
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128910/
https://www.ncbi.nlm.nih.gov/pubmed/27211605
http://dx.doi.org/10.1016/j.critrevonc.2016.04.018
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