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Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity

Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculate...

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Autores principales: Kim, C.-J., Choi, W.S., Jung, Y., Kiem, S., Seol, H.Y., Woo, H.J., Choi, Y.H., Son, J.S., Kim, K.-H., Kim, Y.-S., Kim, E.S., Park, S.H., Yoon, J.H., Choi, S.-M., Lee, H., Oh, W.S., Choi, S.-Y., Kim, N.-J., Choi, J.-P., Park, S.Y., Kim, J., Jeong, S.J., Lee, K.S., Jang, H.C., Rhee, J.Y., Kim, B.-N., Bang, J.H., Lee, J.H., Park, S., Kim, H.Y., Choi, J.K., Wi, Y.-M., Choi, H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128923/
https://www.ncbi.nlm.nih.gov/pubmed/27475739
http://dx.doi.org/10.1016/j.cmi.2016.07.017
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author Kim, C.-J.
Choi, W.S.
Jung, Y.
Kiem, S.
Seol, H.Y.
Woo, H.J.
Choi, Y.H.
Son, J.S.
Kim, K.-H.
Kim, Y.-S.
Kim, E.S.
Park, S.H.
Yoon, J.H.
Choi, S.-M.
Lee, H.
Oh, W.S.
Choi, S.-Y.
Kim, N.-J.
Choi, J.-P.
Park, S.Y.
Kim, J.
Jeong, S.J.
Lee, K.S.
Jang, H.C.
Rhee, J.Y.
Kim, B.-N.
Bang, J.H.
Lee, J.H.
Park, S.
Kim, H.Y.
Choi, J.K.
Wi, Y.-M.
Choi, H.J.
author_facet Kim, C.-J.
Choi, W.S.
Jung, Y.
Kiem, S.
Seol, H.Y.
Woo, H.J.
Choi, Y.H.
Son, J.S.
Kim, K.-H.
Kim, Y.-S.
Kim, E.S.
Park, S.H.
Yoon, J.H.
Choi, S.-M.
Lee, H.
Oh, W.S.
Choi, S.-Y.
Kim, N.-J.
Choi, J.-P.
Park, S.Y.
Kim, J.
Jeong, S.J.
Lee, K.S.
Jang, H.C.
Rhee, J.Y.
Kim, B.-N.
Bang, J.H.
Lee, J.H.
Park, S.
Kim, H.Y.
Choi, J.K.
Wi, Y.-M.
Choi, H.J.
author_sort Kim, C.-J.
collection PubMed
description Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculated the incidence of MERS-affected cases in HCWs. We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4 to 6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. In total, 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs, 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two (0.3%) of these 12 participants. Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2/294) compared to 0% (0/443) in cases with appropriate PPE use. The incidence of MERS infection in HCWs was 1.5% (17/1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE.
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spelling pubmed-71289232020-04-08 Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity Kim, C.-J. Choi, W.S. Jung, Y. Kiem, S. Seol, H.Y. Woo, H.J. Choi, Y.H. Son, J.S. Kim, K.-H. Kim, Y.-S. Kim, E.S. Park, S.H. Yoon, J.H. Choi, S.-M. Lee, H. Oh, W.S. Choi, S.-Y. Kim, N.-J. Choi, J.-P. Park, S.Y. Kim, J. Jeong, S.J. Lee, K.S. Jang, H.C. Rhee, J.Y. Kim, B.-N. Bang, J.H. Lee, J.H. Park, S. Kim, H.Y. Choi, J.K. Wi, Y.-M. Choi, H.J. Clin Microbiol Infect Original Article Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculated the incidence of MERS-affected cases in HCWs. We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4 to 6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. In total, 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs, 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two (0.3%) of these 12 participants. Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2/294) compared to 0% (0/443) in cases with appropriate PPE use. The incidence of MERS infection in HCWs was 1.5% (17/1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. 2016-10 2016-07-27 /pmc/articles/PMC7128923/ /pubmed/27475739 http://dx.doi.org/10.1016/j.cmi.2016.07.017 Text en © 2016 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Kim, C.-J.
Choi, W.S.
Jung, Y.
Kiem, S.
Seol, H.Y.
Woo, H.J.
Choi, Y.H.
Son, J.S.
Kim, K.-H.
Kim, Y.-S.
Kim, E.S.
Park, S.H.
Yoon, J.H.
Choi, S.-M.
Lee, H.
Oh, W.S.
Choi, S.-Y.
Kim, N.-J.
Choi, J.-P.
Park, S.Y.
Kim, J.
Jeong, S.J.
Lee, K.S.
Jang, H.C.
Rhee, J.Y.
Kim, B.-N.
Bang, J.H.
Lee, J.H.
Park, S.
Kim, H.Y.
Choi, J.K.
Wi, Y.-M.
Choi, H.J.
Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title_full Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title_fullStr Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title_full_unstemmed Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title_short Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
title_sort surveillance of the middle east respiratory syndrome (mers) coronavirus (cov) infection in healthcare workers after contact with confirmed mers patients: incidence and risk factors of mers-cov seropositivity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128923/
https://www.ncbi.nlm.nih.gov/pubmed/27475739
http://dx.doi.org/10.1016/j.cmi.2016.07.017
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