Why Aging T Cells Fail: Implications for Vaccination

The decline in CD4(+) T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly.

Detalles Bibliográficos
Autores principales: Haynes, Laura, Swain, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129126/
https://www.ncbi.nlm.nih.gov/pubmed/16782020
http://dx.doi.org/10.1016/j.immuni.2006.06.003
Descripción
Sumario:The decline in CD4(+) T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly.

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