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Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.

Many species of genus Bupleurum L. have been pharmaceutically used mainly in Asia and Europe for thousand years. Their roots are the most popular ingredients in Chinese materia medica prescriptions for the treatment of inflammatory diseases and auto-immune diseases. A plenty of chemical constituents...

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Detalles Bibliográficos
Autores principales: YAO, Ru-yu, ZOU, Yuan-feng, CHEN, Xing-fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tianjin Press of Chinese Herbal Medicines. Published by Elsevier (Singapore) Pte Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129159/
https://www.ncbi.nlm.nih.gov/pubmed/32288759
http://dx.doi.org/10.1016/S1674-6384(13)60036-2
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author YAO, Ru-yu
ZOU, Yuan-feng
CHEN, Xing-fu
author_facet YAO, Ru-yu
ZOU, Yuan-feng
CHEN, Xing-fu
author_sort YAO, Ru-yu
collection PubMed
description Many species of genus Bupleurum L. have been pharmaceutically used mainly in Asia and Europe for thousand years. Their roots are the most popular ingredients in Chinese materia medica prescriptions for the treatment of inflammatory diseases and auto-immune diseases. A plenty of chemical constituents have been isolated and identified from the species in Bupleurum L., such as saikosaponins, polysaccharides, volatile oils, flavonoids, polyacetylenes, lignins, and coumarins, most of which possess a variety of biological activities, especially for the hepatoprotective effect, antitumor activity, immunoregulation, and febrifuge efficacy. Therefore, the species in genus Bupleurum L. could be potential herbs of immunomodulator, antineoplastic, anti-oxidant, etc. Meanwhile, as potential toxicities have been discovered in some constituents, it is urgent to establish a comprehensive quality evaluation system to ensure the safety and efficiency of herbs. This paper reviews on the phytochemical and pharmacological studies, especially for the toxicology and quality control of the species in Bupleurum L., which is a reference for the species in this genus for safe usage and further development.
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spelling pubmed-71291592020-04-08 Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L. YAO, Ru-yu ZOU, Yuan-feng CHEN, Xing-fu Chin Herb Med Article Many species of genus Bupleurum L. have been pharmaceutically used mainly in Asia and Europe for thousand years. Their roots are the most popular ingredients in Chinese materia medica prescriptions for the treatment of inflammatory diseases and auto-immune diseases. A plenty of chemical constituents have been isolated and identified from the species in Bupleurum L., such as saikosaponins, polysaccharides, volatile oils, flavonoids, polyacetylenes, lignins, and coumarins, most of which possess a variety of biological activities, especially for the hepatoprotective effect, antitumor activity, immunoregulation, and febrifuge efficacy. Therefore, the species in genus Bupleurum L. could be potential herbs of immunomodulator, antineoplastic, anti-oxidant, etc. Meanwhile, as potential toxicities have been discovered in some constituents, it is urgent to establish a comprehensive quality evaluation system to ensure the safety and efficiency of herbs. This paper reviews on the phytochemical and pharmacological studies, especially for the toxicology and quality control of the species in Bupleurum L., which is a reference for the species in this genus for safe usage and further development. Tianjin Press of Chinese Herbal Medicines. Published by Elsevier (Singapore) Pte Ltd. 2013-11 2013-11-23 /pmc/articles/PMC7129159/ /pubmed/32288759 http://dx.doi.org/10.1016/S1674-6384(13)60036-2 Text en Copyright © 2013 Tianjin Press of Chinese Herbal Medicines. Published by Elsevier (Singapore) Pte Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
YAO, Ru-yu
ZOU, Yuan-feng
CHEN, Xing-fu
Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title_full Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title_fullStr Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title_full_unstemmed Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title_short Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.
title_sort traditional use, pharmacology, toxicology, and quality control of species in genus bupleurum l.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129159/
https://www.ncbi.nlm.nih.gov/pubmed/32288759
http://dx.doi.org/10.1016/S1674-6384(13)60036-2
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