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Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()

INTRODUCTION: In 2005 a new respiratory virus, called human bocavirus (HBoV), was cloned from respiratory samples from Swedish infants and children with lower respiratory tract infections. OBJECTIVES: To determine whether HBoV has circulated in Spain, estimate the frequency of HBoV infections in pat...

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Autores principales: García-García, M.L., Calvo Rey, C., Pozo Sánchez, F., Vázquez Álvarez, M.C., González Vergaz, A., Pérez-Breña, P., Casas Flecha, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asociación Española de Pediatría. Published by Elsevier España S.L. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129226/
https://www.ncbi.nlm.nih.gov/pubmed/17785157
http://dx.doi.org/10.1016/S1695-4033(07)70609-4
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author García-García, M.L.
Calvo Rey, C.
Pozo Sánchez, F.
Vázquez Álvarez, M.C.
González Vergaz, A.
Pérez-Breña, P.
Casas Flecha, I.
author_facet García-García, M.L.
Calvo Rey, C.
Pozo Sánchez, F.
Vázquez Álvarez, M.C.
González Vergaz, A.
Pérez-Breña, P.
Casas Flecha, I.
author_sort García-García, M.L.
collection PubMed
description INTRODUCTION: In 2005 a new respiratory virus, called human bocavirus (HBoV), was cloned from respiratory samples from Swedish infants and children with lower respiratory tract infections. OBJECTIVES: To determine whether HBoV has circulated in Spain, estimate the frequency of HBoV infections in patients hospitalized for respiratory infection and describe the clinical and epidemiological characteristics of these patients. PATIENTS AND METHODS: We performed a descriptive prospective study of confirmed HBoV infections in patients aged < 14 years old, hospitalized for respiratory infections between October 2004 and June 2005. Virologic diagnosis was based on multiple RT-PCR for respiratory syncytial virus (RSV) A and B, influenza A,B, and C, parainfluenza 1-4, adenovirus and rhinovirus; PCR was used for human metapneumovirus (hMPV) and PCR in nasopharyngeal aspirates was used for HBoV. The clinical and epidemiological characteristics of patients were analyzed. RESULTS: Fifty-two cases of HBoV infection were detected, representing 17.1 % (95 % CI: 13 % a 21 %) of patients hospitalized for respiratory infections. HBoV was the third most frequent viral agent after RSV (30 %) and rhinovirus (25 %). In 39 patients (71.1 %) coinfection with another respiratory virus was detected. Fifty percent of the patients were aged less than 13.6 months and 75 % were aged less than 2 years. The most frequent diagnoses were recurrent wheezing (55.8 %), bronchiolitis (21.2 %) and pneumonia (15.4 %). Clinical sepsis with petechial exanthema was found in two patients. Fever > 38 °C was found in 72.1 % and radiological infiltrate in 44 %. Hypoxia was present in 55.8 % of the patients. HBoV was isolated in distinct episodes in two patients. Coinfections were similar to simple infections except that hypoxia was more frequent in the former (p 0.038). CONCLUSIONS: HBoV is one of the most frequent viruses in severe respiratory infections in patients aged less than 14 years old. Only RSV and rhinovirus are more frequent. Coinfections are highly frequent. Most patients are infants with recurrent wheezing and bronchiolitis.
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spelling pubmed-71292262020-04-08 Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente() García-García, M.L. Calvo Rey, C. Pozo Sánchez, F. Vázquez Álvarez, M.C. González Vergaz, A. Pérez-Breña, P. Casas Flecha, I. An Pediatr (Barc) Originales INTRODUCTION: In 2005 a new respiratory virus, called human bocavirus (HBoV), was cloned from respiratory samples from Swedish infants and children with lower respiratory tract infections. OBJECTIVES: To determine whether HBoV has circulated in Spain, estimate the frequency of HBoV infections in patients hospitalized for respiratory infection and describe the clinical and epidemiological characteristics of these patients. PATIENTS AND METHODS: We performed a descriptive prospective study of confirmed HBoV infections in patients aged < 14 years old, hospitalized for respiratory infections between October 2004 and June 2005. Virologic diagnosis was based on multiple RT-PCR for respiratory syncytial virus (RSV) A and B, influenza A,B, and C, parainfluenza 1-4, adenovirus and rhinovirus; PCR was used for human metapneumovirus (hMPV) and PCR in nasopharyngeal aspirates was used for HBoV. The clinical and epidemiological characteristics of patients were analyzed. RESULTS: Fifty-two cases of HBoV infection were detected, representing 17.1 % (95 % CI: 13 % a 21 %) of patients hospitalized for respiratory infections. HBoV was the third most frequent viral agent after RSV (30 %) and rhinovirus (25 %). In 39 patients (71.1 %) coinfection with another respiratory virus was detected. Fifty percent of the patients were aged less than 13.6 months and 75 % were aged less than 2 years. The most frequent diagnoses were recurrent wheezing (55.8 %), bronchiolitis (21.2 %) and pneumonia (15.4 %). Clinical sepsis with petechial exanthema was found in two patients. Fever > 38 °C was found in 72.1 % and radiological infiltrate in 44 %. Hypoxia was present in 55.8 % of the patients. HBoV was isolated in distinct episodes in two patients. Coinfections were similar to simple infections except that hypoxia was more frequent in the former (p 0.038). CONCLUSIONS: HBoV is one of the most frequent viruses in severe respiratory infections in patients aged less than 14 years old. Only RSV and rhinovirus are more frequent. Coinfections are highly frequent. Most patients are infants with recurrent wheezing and bronchiolitis. Asociación Española de Pediatría. Published by Elsevier España S.L. 2007-09 2009-01-06 /pmc/articles/PMC7129226/ /pubmed/17785157 http://dx.doi.org/10.1016/S1695-4033(07)70609-4 Text en Copyright © 2007 Asociación Española de Pediatría. Published by Elsevier España S.L. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Originales
García-García, M.L.
Calvo Rey, C.
Pozo Sánchez, F.
Vázquez Álvarez, M.C.
González Vergaz, A.
Pérez-Breña, P.
Casas Flecha, I.
Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title_full Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title_fullStr Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title_full_unstemmed Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title_short Infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
title_sort infecciones por bocavirus humano en niños españoles: características clínicas y epidemiológicas de un virus respiratorio emergente()
topic Originales
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129226/
https://www.ncbi.nlm.nih.gov/pubmed/17785157
http://dx.doi.org/10.1016/S1695-4033(07)70609-4
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