Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak

To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Jae-Hoon, Seok, Hyeri, Park, Ga Eun, Lee, Ji Yeon, Lee, Ji Yong, Cho, Sun Young, Ha, Young Eun, Kang, Ji-Man, Kim, Yae-Jean, Kang, Cheol-In, Chung, Doo Ryeon, Song, Jae-Hoon, Peck, Kyong Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2018
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129617/
https://www.ncbi.nlm.nih.gov/pubmed/29223614
http://dx.doi.org/10.1016/j.jiac.2017.09.008
Descripción
Sumario:To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447–178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402–13.761; P = 0.011) were significantly associated with MERS-CoV infection.

Ejemplares similares