Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak

To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of whi...

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Autores principales: Ko, Jae-Hoon, Seok, Hyeri, Park, Ga Eun, Lee, Ji Yeon, Lee, Ji Yong, Cho, Sun Young, Ha, Young Eun, Kang, Ji-Man, Kim, Yae-Jean, Kang, Cheol-In, Chung, Doo Ryeon, Song, Jae-Hoon, Peck, Kyong Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2018
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129617/
https://www.ncbi.nlm.nih.gov/pubmed/29223614
http://dx.doi.org/10.1016/j.jiac.2017.09.008
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author Ko, Jae-Hoon
Seok, Hyeri
Park, Ga Eun
Lee, Ji Yeon
Lee, Ji Yong
Cho, Sun Young
Ha, Young Eun
Kang, Ji-Man
Kim, Yae-Jean
Kang, Cheol-In
Chung, Doo Ryeon
Song, Jae-Hoon
Peck, Kyong Ran
author_facet Ko, Jae-Hoon
Seok, Hyeri
Park, Ga Eun
Lee, Ji Yeon
Lee, Ji Yong
Cho, Sun Young
Ha, Young Eun
Kang, Ji-Man
Kim, Yae-Jean
Kang, Cheol-In
Chung, Doo Ryeon
Song, Jae-Hoon
Peck, Kyong Ran
author_sort Ko, Jae-Hoon
collection PubMed
description To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447–178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402–13.761; P = 0.011) were significantly associated with MERS-CoV infection.
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spelling pubmed-71296172020-04-08 Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak Ko, Jae-Hoon Seok, Hyeri Park, Ga Eun Lee, Ji Yeon Lee, Ji Yong Cho, Sun Young Ha, Young Eun Kang, Ji-Man Kim, Yae-Jean Kang, Cheol-In Chung, Doo Ryeon Song, Jae-Hoon Peck, Kyong Ran J Infect Chemother Note To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447–178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402–13.761; P = 0.011) were significantly associated with MERS-CoV infection. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2018-02 2017-12-06 /pmc/articles/PMC7129617/ /pubmed/29223614 http://dx.doi.org/10.1016/j.jiac.2017.09.008 Text en © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Note
Ko, Jae-Hoon
Seok, Hyeri
Park, Ga Eun
Lee, Ji Yeon
Lee, Ji Yong
Cho, Sun Young
Ha, Young Eun
Kang, Ji-Man
Kim, Yae-Jean
Kang, Cheol-In
Chung, Doo Ryeon
Song, Jae-Hoon
Peck, Kyong Ran
Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title_full Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title_fullStr Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title_full_unstemmed Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title_short Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak
title_sort host susceptibility to mers-cov infection, a retrospective cohort study of the 2015 korean mers outbreak
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129617/
https://www.ncbi.nlm.nih.gov/pubmed/29223614
http://dx.doi.org/10.1016/j.jiac.2017.09.008
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