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Mendelian resistance to human norovirus infections
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood grou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129677/ https://www.ncbi.nlm.nih.gov/pubmed/16973373 http://dx.doi.org/10.1016/j.smim.2006.07.009 |
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author | Le Pendu, Jacques Ruvoën-Clouet, Nathalie Kindberg, Elin Svensson, Lennart |
author_facet | Le Pendu, Jacques Ruvoën-Clouet, Nathalie Kindberg, Elin Svensson, Lennart |
author_sort | Le Pendu, Jacques |
collection | PubMed |
description | Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2−/−), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host–pathogen co-evolution driven by carbohydrate–protein interactions. |
format | Online Article Text |
id | pubmed-7129677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71296772020-04-08 Mendelian resistance to human norovirus infections Le Pendu, Jacques Ruvoën-Clouet, Nathalie Kindberg, Elin Svensson, Lennart Semin Immunol Review Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2−/−), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host–pathogen co-evolution driven by carbohydrate–protein interactions. Published by Elsevier Ltd. 2006-12 2006-09-14 /pmc/articles/PMC7129677/ /pubmed/16973373 http://dx.doi.org/10.1016/j.smim.2006.07.009 Text en Copyright © 2006 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Le Pendu, Jacques Ruvoën-Clouet, Nathalie Kindberg, Elin Svensson, Lennart Mendelian resistance to human norovirus infections |
title | Mendelian resistance to human norovirus infections |
title_full | Mendelian resistance to human norovirus infections |
title_fullStr | Mendelian resistance to human norovirus infections |
title_full_unstemmed | Mendelian resistance to human norovirus infections |
title_short | Mendelian resistance to human norovirus infections |
title_sort | mendelian resistance to human norovirus infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129677/ https://www.ncbi.nlm.nih.gov/pubmed/16973373 http://dx.doi.org/10.1016/j.smim.2006.07.009 |
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