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Mendelian resistance to human norovirus infections

Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood grou...

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Autores principales: Le Pendu, Jacques, Ruvoën-Clouet, Nathalie, Kindberg, Elin, Svensson, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129677/
https://www.ncbi.nlm.nih.gov/pubmed/16973373
http://dx.doi.org/10.1016/j.smim.2006.07.009
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author Le Pendu, Jacques
Ruvoën-Clouet, Nathalie
Kindberg, Elin
Svensson, Lennart
author_facet Le Pendu, Jacques
Ruvoën-Clouet, Nathalie
Kindberg, Elin
Svensson, Lennart
author_sort Le Pendu, Jacques
collection PubMed
description Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2−/−), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host–pathogen co-evolution driven by carbohydrate–protein interactions.
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spelling pubmed-71296772020-04-08 Mendelian resistance to human norovirus infections Le Pendu, Jacques Ruvoën-Clouet, Nathalie Kindberg, Elin Svensson, Lennart Semin Immunol Review Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2−/−), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host–pathogen co-evolution driven by carbohydrate–protein interactions. Published by Elsevier Ltd. 2006-12 2006-09-14 /pmc/articles/PMC7129677/ /pubmed/16973373 http://dx.doi.org/10.1016/j.smim.2006.07.009 Text en Copyright © 2006 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Le Pendu, Jacques
Ruvoën-Clouet, Nathalie
Kindberg, Elin
Svensson, Lennart
Mendelian resistance to human norovirus infections
title Mendelian resistance to human norovirus infections
title_full Mendelian resistance to human norovirus infections
title_fullStr Mendelian resistance to human norovirus infections
title_full_unstemmed Mendelian resistance to human norovirus infections
title_short Mendelian resistance to human norovirus infections
title_sort mendelian resistance to human norovirus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129677/
https://www.ncbi.nlm.nih.gov/pubmed/16973373
http://dx.doi.org/10.1016/j.smim.2006.07.009
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