Mouse hepatitis virus

Inoculation of mice with most neurotropic strains of the coronavirus mouse hepatitis virus results in an immune response-mediated demyelinating disease that serves as an excellent animal model for the human disease multiple sclerosis. Recent work has shown that either virus-specific CD4(+) or CD8(+)...

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Detalles Bibliográficos
Autores principales: Haring, Jodie, Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2001
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129732/
https://www.ncbi.nlm.nih.gov/pubmed/11495812
http://dx.doi.org/10.1016/S1369-5274(00)00236-8
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author Haring, Jodie
Perlman, Stanley
author_facet Haring, Jodie
Perlman, Stanley
author_sort Haring, Jodie
collection PubMed
description Inoculation of mice with most neurotropic strains of the coronavirus mouse hepatitis virus results in an immune response-mediated demyelinating disease that serves as an excellent animal model for the human disease multiple sclerosis. Recent work has shown that either virus-specific CD4(+) or CD8(+) T cells are able to mediate demyelination and also that the antibody response is crucial for clearing infectious virus. Another exciting advance is the development of recombinant coronaviruses, which, for the first time, will allow genetic manipulation of the entire viral genome.
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spelling pubmed-71297322020-04-08 Mouse hepatitis virus Haring, Jodie Perlman, Stanley Curr Opin Microbiol Review Inoculation of mice with most neurotropic strains of the coronavirus mouse hepatitis virus results in an immune response-mediated demyelinating disease that serves as an excellent animal model for the human disease multiple sclerosis. Recent work has shown that either virus-specific CD4(+) or CD8(+) T cells are able to mediate demyelination and also that the antibody response is crucial for clearing infectious virus. Another exciting advance is the development of recombinant coronaviruses, which, for the first time, will allow genetic manipulation of the entire viral genome. Elsevier Science Ltd. 2001-08-01 2001-08-03 /pmc/articles/PMC7129732/ /pubmed/11495812 http://dx.doi.org/10.1016/S1369-5274(00)00236-8 Text en Copyright © 2001 Elsevier Science Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Haring, Jodie
Perlman, Stanley
Mouse hepatitis virus
title Mouse hepatitis virus
title_full Mouse hepatitis virus
title_fullStr Mouse hepatitis virus
title_full_unstemmed Mouse hepatitis virus
title_short Mouse hepatitis virus
title_sort mouse hepatitis virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129732/
https://www.ncbi.nlm.nih.gov/pubmed/11495812
http://dx.doi.org/10.1016/S1369-5274(00)00236-8
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