Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency

Interferon lambda 4 (IFNλ4) has been recently known and studied for its role in hepatitis C virus (HCV) infection, but its clinical potential is significantly hampered due to its poor expression in vitro. Our study reports the successful production of IFNλ4 from a mammalian cell line through a glyco...

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Detalles Bibliográficos
Autores principales: Chung, Jae-Hee, Hong, Seon-Hui, Seo, Nari, Kim, Tae-Shin, An, Hyun Joo, Lee, Pedro, Shin, Eui-Cheol, Kim, Ho Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129780/
https://www.ncbi.nlm.nih.gov/pubmed/31479875
http://dx.doi.org/10.1016/j.cyto.2019.154833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129780/
https://www.ncbi.nlm.nih.gov/pubmed/31479875
http://dx.doi.org/10.1016/j.cyto.2019.154833

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