Cargando…

Biophysical characterization of HRC peptide analogs interaction with heptad repeat regions of the SARS-coronavirus Spike fusion protein core

The Spike (S) protein of SARS-coronavirus (SARS-CoV) mediates viral entry into host cells. It contains two heptad repeat regions, denoted HRN and HRC. We have identified the location of the two interacting HR regions that form the six-helix bundle (B. Tripet, et al, J. Biol. Chem., 279: 20836–20849,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Zhe, Tripet, Brian, Hodges, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129827/
https://www.ncbi.nlm.nih.gov/pubmed/16765058
http://dx.doi.org/10.1016/j.jsb.2006.03.024