Cargando…

IL-12 and Viral Infections

Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experime...

Descripción completa

Detalles Bibliográficos
Autores principales: Komastu, Takashi, Ireland, Derek D.C, Reiss, Carol Shoshkes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129962/
https://www.ncbi.nlm.nih.gov/pubmed/9918125
http://dx.doi.org/10.1016/S1359-6101(98)00017-3
_version_ 1783516903779598336
author Komastu, Takashi
Ireland, Derek D.C
Reiss, Carol Shoshkes
author_facet Komastu, Takashi
Ireland, Derek D.C
Reiss, Carol Shoshkes
author_sort Komastu, Takashi
collection PubMed
description Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experimental studies have shown that administration of the cytokine rapidly activates both innate and specific immune responses; this results in enhanced host cellular responses and generally, promotes clearance of virus and host recovery from infection. The observations of many laboratories, studying viral immunity to both RNA and DNA based pathogens, are summarized.
format Online
Article
Text
id pubmed-7129962
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Elsevier Science Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71299622020-04-08 IL-12 and Viral Infections Komastu, Takashi Ireland, Derek D.C Reiss, Carol Shoshkes Cytokine Growth Factor Rev Article Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experimental studies have shown that administration of the cytokine rapidly activates both innate and specific immune responses; this results in enhanced host cellular responses and generally, promotes clearance of virus and host recovery from infection. The observations of many laboratories, studying viral immunity to both RNA and DNA based pathogens, are summarized. Elsevier Science Ltd. 1998-12-01 1999-01-08 /pmc/articles/PMC7129962/ /pubmed/9918125 http://dx.doi.org/10.1016/S1359-6101(98)00017-3 Text en Copyright © 1998 Elsevier Science Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Komastu, Takashi
Ireland, Derek D.C
Reiss, Carol Shoshkes
IL-12 and Viral Infections
title IL-12 and Viral Infections
title_full IL-12 and Viral Infections
title_fullStr IL-12 and Viral Infections
title_full_unstemmed IL-12 and Viral Infections
title_short IL-12 and Viral Infections
title_sort il-12 and viral infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129962/
https://www.ncbi.nlm.nih.gov/pubmed/9918125
http://dx.doi.org/10.1016/S1359-6101(98)00017-3
work_keys_str_mv AT komastutakashi il12andviralinfections
AT irelandderekdc il12andviralinfections
AT reisscarolshoshkes il12andviralinfections