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IL-12 and Viral Infections
Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experime...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Ltd.
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129962/ https://www.ncbi.nlm.nih.gov/pubmed/9918125 http://dx.doi.org/10.1016/S1359-6101(98)00017-3 |
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author | Komastu, Takashi Ireland, Derek D.C Reiss, Carol Shoshkes |
author_facet | Komastu, Takashi Ireland, Derek D.C Reiss, Carol Shoshkes |
author_sort | Komastu, Takashi |
collection | PubMed |
description | Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experimental studies have shown that administration of the cytokine rapidly activates both innate and specific immune responses; this results in enhanced host cellular responses and generally, promotes clearance of virus and host recovery from infection. The observations of many laboratories, studying viral immunity to both RNA and DNA based pathogens, are summarized. |
format | Online Article Text |
id | pubmed-7129962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Elsevier Science Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71299622020-04-08 IL-12 and Viral Infections Komastu, Takashi Ireland, Derek D.C Reiss, Carol Shoshkes Cytokine Growth Factor Rev Article Interleukin-12 activates natural killer cells and promotes the differentiation of Th1 CD4+ cells; it is a critical factor in viral immunity. IL-12 is secreted by antigen presenting cells including dendritic cells, macrophages and astrocytes, both in tissues and in secondary lymphoid organs. Experimental studies have shown that administration of the cytokine rapidly activates both innate and specific immune responses; this results in enhanced host cellular responses and generally, promotes clearance of virus and host recovery from infection. The observations of many laboratories, studying viral immunity to both RNA and DNA based pathogens, are summarized. Elsevier Science Ltd. 1998-12-01 1999-01-08 /pmc/articles/PMC7129962/ /pubmed/9918125 http://dx.doi.org/10.1016/S1359-6101(98)00017-3 Text en Copyright © 1998 Elsevier Science Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Komastu, Takashi Ireland, Derek D.C Reiss, Carol Shoshkes IL-12 and Viral Infections |
title | IL-12 and Viral Infections |
title_full | IL-12 and Viral Infections |
title_fullStr | IL-12 and Viral Infections |
title_full_unstemmed | IL-12 and Viral Infections |
title_short | IL-12 and Viral Infections |
title_sort | il-12 and viral infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129962/ https://www.ncbi.nlm.nih.gov/pubmed/9918125 http://dx.doi.org/10.1016/S1359-6101(98)00017-3 |
work_keys_str_mv | AT komastutakashi il12andviralinfections AT irelandderekdc il12andviralinfections AT reisscarolshoshkes il12andviralinfections |