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Barrier stabilizing mediators in regulation of microvascular endothelial permeability

Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, resulting in formation of severe tissu...

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Autores principales: Qiao-bing, Huang, Min, Dong, Shuang-ming, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Daping hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129994/
https://www.ncbi.nlm.nih.gov/pubmed/22480675
http://dx.doi.org/10.3760/cma.j.issn.1008-1275.2012.02.008
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author Qiao-bing, Huang
Min, Dong
Shuang-ming, Song
author_facet Qiao-bing, Huang
Min, Dong
Shuang-ming, Song
author_sort Qiao-bing, Huang
collection PubMed
description Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, resulting in formation of severe tissue edema, hypotension or even shock, especially in severe burn injury. Fluid resuscitation has been the only valid approach to sustain patient’s blood volume for a long time, due to the lack of overall and profound understanding of the mechanisms of vascular hyperpermeability response. There is an emerging concept in recent years that some so-called barrier stabilizing mediators play a positive role in preventing the increase of vascular permeability. These mediators may be released in response to proinflammatory mediators and serve to restore endothelial barrier function. Some of these stabilizing mediators are important even in quiescent state because they preserve basal vascular permeability at low levels. This review introduces some of these mediators and reveals their underlying signaling mechanisms during endothelial barrier enhancing process.
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spelling pubmed-71299942020-04-08 Barrier stabilizing mediators in regulation of microvascular endothelial permeability Qiao-bing, Huang Min, Dong Shuang-ming, Song Chin J Traumatol Article Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, resulting in formation of severe tissue edema, hypotension or even shock, especially in severe burn injury. Fluid resuscitation has been the only valid approach to sustain patient’s blood volume for a long time, due to the lack of overall and profound understanding of the mechanisms of vascular hyperpermeability response. There is an emerging concept in recent years that some so-called barrier stabilizing mediators play a positive role in preventing the increase of vascular permeability. These mediators may be released in response to proinflammatory mediators and serve to restore endothelial barrier function. Some of these stabilizing mediators are important even in quiescent state because they preserve basal vascular permeability at low levels. This review introduces some of these mediators and reveals their underlying signaling mechanisms during endothelial barrier enhancing process. Daping hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. 2012-04 2016-02-01 /pmc/articles/PMC7129994/ /pubmed/22480675 http://dx.doi.org/10.3760/cma.j.issn.1008-1275.2012.02.008 Text en © 2012 Daping hospital and the Research Institute of Surgery of the Third Military Medical University Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Qiao-bing, Huang
Min, Dong
Shuang-ming, Song
Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title_full Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title_fullStr Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title_full_unstemmed Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title_short Barrier stabilizing mediators in regulation of microvascular endothelial permeability
title_sort barrier stabilizing mediators in regulation of microvascular endothelial permeability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129994/
https://www.ncbi.nlm.nih.gov/pubmed/22480675
http://dx.doi.org/10.3760/cma.j.issn.1008-1275.2012.02.008
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