Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a Novel Selective Estrogen Receptor Modulator

The benzo[b]furan derivative MU314 inhibits in vitro bone resorption as potently as β-estradiol (E(2)). Here, we examined the point of action on the anti-osteoporotic effects of MU314. MU314 (10 nM) suppressed lacunae formation by osteoclastic cells and ICI-182,780, a pure E(2) antagonist, inhibited...

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Detalles Bibliográficos
Autores principales: Fukuyama, Ryo, Shimokawa, Akio, Kodama, Yasushi, Fujita, Mitsugu, Ohishi, Yoshitaka, Ando, Yuko, Koida, Masao, Nakamuta, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. Production and hosting by Elsevier B.V. 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130049/
https://www.ncbi.nlm.nih.gov/pubmed/21606624
http://dx.doi.org/10.1254/jphs.11049FP

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