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O030 Evasion of the OAS-RNase L pathway by murine coronavirus ns2 protein is required for viral replication and hepatitis
INTRODUCTION: The 2′,5′-oligoadenylate synthetase-ribonuclease L (OAS-RNase L) system is a potent IFN induced antiviral pathway. Following infection, IFNs induce a group of OAS genes whose products are activated by viral double-stranded RNA. OAS uses ATP to generate 2′,5′-linked oligoadenylates (2-5...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Ltd.
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130074/ http://dx.doi.org/10.1016/j.cyto.2012.06.064 |