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Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve
An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [(3)H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier B.V.
1992
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130121/ https://www.ncbi.nlm.nih.gov/pubmed/1378089 http://dx.doi.org/10.1016/0022-510X(92)90194-P |
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author | Jenkins, Huw G. Ikeda, Hisako |
author_facet | Jenkins, Huw G. Ikeda, Hisako |
author_sort | Jenkins, Huw G. |
collection | PubMed |
description | An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [(3)H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis. |
format | Online Article Text |
id | pubmed-7130121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1992 |
publisher | Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71301212020-04-08 Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve Jenkins, Huw G. Ikeda, Hisako J Neurol Sci Article An increase in fast axonal transport of protein by the optic nerve was found in mice following a single combined injection of human recombinant tumour necrosis factor alpha (rTNF) and [(3)H]proline into the vitreous chamber. Demyelination was observed in optic nerve fibres arising from the eyes of mice which received a single rTNF injection. No such changes were detected when heat-inactivated rTNF was injected with the label. The effects of intravitreal injection of rTNF on the pathophysiology of mouse optic nerve resembled those found in mice infected with Semliki Forest virus (SFV), an animal model of multiple sclerosis. We suggest that TNF could mediate at lease some of the pathophysiological changes found in SFV-infected mice and may provide a clue concerning the disease mechanism in multiple sclerosis. Published by Elsevier B.V. 1992-03 2003-03-14 /pmc/articles/PMC7130121/ /pubmed/1378089 http://dx.doi.org/10.1016/0022-510X(92)90194-P Text en Copyright © 1992 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Jenkins, Huw G. Ikeda, Hisako Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title | Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title_full | Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title_fullStr | Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title_full_unstemmed | Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title_short | Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
title_sort | tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130121/ https://www.ncbi.nlm.nih.gov/pubmed/1378089 http://dx.doi.org/10.1016/0022-510X(92)90194-P |
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