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Colonic Compensation in Transmissible Gastroenteritis of Swine

Absorption of water and electrolytes by the small and large intestine was examined using a nonabsorbable marker technique in 3-day-old and 3-wkold pigs. One-half of the pigs in each group were orally infected with transmissible gastroenteritis virus; the remaining pigs served as controls. Threeday-o...

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Autores principales: Argenzio, R.A., Moon, H.W., Kemeny, L.J., Whipp, S.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Gastroenterological Association. Published by Elsevier Inc. 1984
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130427/
https://www.ncbi.nlm.nih.gov/pubmed/6714576
http://dx.doi.org/10.1016/S0016-5085(84)80165-1
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author Argenzio, R.A.
Moon, H.W.
Kemeny, L.J.
Whipp, S.C.
author_facet Argenzio, R.A.
Moon, H.W.
Kemeny, L.J.
Whipp, S.C.
author_sort Argenzio, R.A.
collection PubMed
description Absorption of water and electrolytes by the small and large intestine was examined using a nonabsorbable marker technique in 3-day-old and 3-wkold pigs. One-half of the pigs in each group were orally infected with transmissible gastroenteritis virus; the remaining pigs served as controls. Threeday-old control pigs concentrated the nonabsorbable fluid marker twelve f old along the small and large intestine, indicating an efficiency of about 95% in absorption of the exogenous daily fluid load presented to the intestine. In contrast, the marker concentration in infected pigs showed no change whatsoever along either the small or large intestine, indicating a complete absence of net fluid absorption or secretion in these animals. Three-week-old control pigs concentrated the marker similarly to the 3-day-old group, with the bulk of the fluid absorption occurring in the small intestine. Infected pigs in the 3-wk-old group had marked net fluid secretion in the proximal small intestine, so that about twice the fluid load was presented to the large intestine of the 3-wk-old infected pigs as compared to the 3-day-old infected group. However, in contrast to the 3-day-old infected group, the large intestine of the 3-wk-old infected pigs increased fluid absorption some six times over the control, and this compensatory response prevented diarrhea in these older animals. Analysis of luminal contents indicated that in the older pigs, unabsorbed carbohydrate was almost completely fermented to short-chain fatty acids in the colon, whereas in the younger pigs the carbohydrate passed through the colon unchanged. These results demonstrate that development of microbial digestion, together with rapid short-chain fatty acid absorption, is a primary feature responsible for the colonic compensation in the older pigs with transmissible gastroenteritis.
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spelling pubmed-71304272020-04-08 Colonic Compensation in Transmissible Gastroenteritis of Swine Argenzio, R.A. Moon, H.W. Kemeny, L.J. Whipp, S.C. Gastroenterology Article Absorption of water and electrolytes by the small and large intestine was examined using a nonabsorbable marker technique in 3-day-old and 3-wkold pigs. One-half of the pigs in each group were orally infected with transmissible gastroenteritis virus; the remaining pigs served as controls. Threeday-old control pigs concentrated the nonabsorbable fluid marker twelve f old along the small and large intestine, indicating an efficiency of about 95% in absorption of the exogenous daily fluid load presented to the intestine. In contrast, the marker concentration in infected pigs showed no change whatsoever along either the small or large intestine, indicating a complete absence of net fluid absorption or secretion in these animals. Three-week-old control pigs concentrated the marker similarly to the 3-day-old group, with the bulk of the fluid absorption occurring in the small intestine. Infected pigs in the 3-wk-old group had marked net fluid secretion in the proximal small intestine, so that about twice the fluid load was presented to the large intestine of the 3-wk-old infected pigs as compared to the 3-day-old infected group. However, in contrast to the 3-day-old infected group, the large intestine of the 3-wk-old infected pigs increased fluid absorption some six times over the control, and this compensatory response prevented diarrhea in these older animals. Analysis of luminal contents indicated that in the older pigs, unabsorbed carbohydrate was almost completely fermented to short-chain fatty acids in the colon, whereas in the younger pigs the carbohydrate passed through the colon unchanged. These results demonstrate that development of microbial digestion, together with rapid short-chain fatty acid absorption, is a primary feature responsible for the colonic compensation in the older pigs with transmissible gastroenteritis. American Gastroenterological Association. Published by Elsevier Inc. 1984-06 2020-02-14 /pmc/articles/PMC7130427/ /pubmed/6714576 http://dx.doi.org/10.1016/S0016-5085(84)80165-1 Text en © 1984 American Gastroenterological Association Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Argenzio, R.A.
Moon, H.W.
Kemeny, L.J.
Whipp, S.C.
Colonic Compensation in Transmissible Gastroenteritis of Swine
title Colonic Compensation in Transmissible Gastroenteritis of Swine
title_full Colonic Compensation in Transmissible Gastroenteritis of Swine
title_fullStr Colonic Compensation in Transmissible Gastroenteritis of Swine
title_full_unstemmed Colonic Compensation in Transmissible Gastroenteritis of Swine
title_short Colonic Compensation in Transmissible Gastroenteritis of Swine
title_sort colonic compensation in transmissible gastroenteritis of swine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130427/
https://www.ncbi.nlm.nih.gov/pubmed/6714576
http://dx.doi.org/10.1016/S0016-5085(84)80165-1
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