Antigenic homology among coronaviruses related to transmissible gastroenteritis virus

The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV...

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Autores principales: Sánchez, Carlos M., Jiménez, Gustavo, Laviada, María D., Correa, Isabel, Suñé, Carlos, Bullido, María J., Gebauer, Fátima, Smerdou, Cristian, Callebaut, Paul, Escribano, JoséM., Enjuanes, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130632/
https://www.ncbi.nlm.nih.gov/pubmed/1689525
http://dx.doi.org/10.1016/0042-6822(90)90094-8
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author Sánchez, Carlos M.
Jiménez, Gustavo
Laviada, María D.
Correa, Isabel
Suñé, Carlos
Bullido, María J.
Gebauer, Fátima
Smerdou, Cristian
Callebaut, Paul
Escribano, JoséM.
Enjuanes, Luis
author_facet Sánchez, Carlos M.
Jiménez, Gustavo
Laviada, María D.
Correa, Isabel
Suñé, Carlos
Bullido, María J.
Gebauer, Fátima
Smerdou, Cristian
Callebaut, Paul
Escribano, JoséM.
Enjuanes, Luis
author_sort Sánchez, Carlos M.
collection PubMed
description The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV isolates from the respiratory variants. An antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested.
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spelling pubmed-71306322020-04-08 Antigenic homology among coronaviruses related to transmissible gastroenteritis virus Sánchez, Carlos M. Jiménez, Gustavo Laviada, María D. Correa, Isabel Suñé, Carlos Bullido, María J. Gebauer, Fátima Smerdou, Cristian Callebaut, Paul Escribano, JoséM. Enjuanes, Luis Virology Article The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV isolates from the respiratory variants. An antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested. Published by Elsevier Inc. 1990-02 2004-02-06 /pmc/articles/PMC7130632/ /pubmed/1689525 http://dx.doi.org/10.1016/0042-6822(90)90094-8 Text en Copyright © 1990 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sánchez, Carlos M.
Jiménez, Gustavo
Laviada, María D.
Correa, Isabel
Suñé, Carlos
Bullido, María J.
Gebauer, Fátima
Smerdou, Cristian
Callebaut, Paul
Escribano, JoséM.
Enjuanes, Luis
Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title_full Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title_fullStr Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title_full_unstemmed Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title_short Antigenic homology among coronaviruses related to transmissible gastroenteritis virus
title_sort antigenic homology among coronaviruses related to transmissible gastroenteritis virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130632/
https://www.ncbi.nlm.nih.gov/pubmed/1689525
http://dx.doi.org/10.1016/0042-6822(90)90094-8
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