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Proteolysis and antigen presentation by MHC class II molecules

Proteolysis is the primary mechanism used by all cells not only to dispose of unwanted proteins but also to regulate protein function and maintain cellular homeostasis. Proteases that reside in the endocytic pathway are the principal actors of terminal protein degradation. The proteases contained in...

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Autores principales: Bryant, Paula Wolf, Lennon-Duménil, Ana-Maria, Fiebiger, Edda, Lagaudriére-Gesbert, Cécile, Ploegh, Hidde L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130937/
https://www.ncbi.nlm.nih.gov/pubmed/12078484
http://dx.doi.org/10.1016/S0065-2776(02)80013-X
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author Bryant, Paula Wolf
Lennon-Duménil, Ana-Maria
Fiebiger, Edda
Lagaudriére-Gesbert, Cécile
Ploegh, Hidde L
author_facet Bryant, Paula Wolf
Lennon-Duménil, Ana-Maria
Fiebiger, Edda
Lagaudriére-Gesbert, Cécile
Ploegh, Hidde L
author_sort Bryant, Paula Wolf
collection PubMed
description Proteolysis is the primary mechanism used by all cells not only to dispose of unwanted proteins but also to regulate protein function and maintain cellular homeostasis. Proteases that reside in the endocytic pathway are the principal actors of terminal protein degradation. The proteases contained in the endocytic pathway are classified into four major groups based on the active-site amino acid used by the enzyme to hydrolyze amide bonds of proteins: cysteine, aspartyl, serine, and metalloproteases. The presentation of peptide antigens by major histocompatibility complex (MHC) class II molecules is strictly dependent on the action of proteases. Class II molecules scour the endocytic pathway for antigenic peptides to bind and present at the cell surface for recognition by CD4(+) T cells. The specialized cell types that support antigen presentation by class II molecules are commonly referred to as professional antigen presenting cells (APCs), which include bone marrow-derived B lymphocytes, dendritic cells (DCs), and macrophages. In addition, the expression of certain endocytic proteases is regulated either at the level of gene transcription or enzyme maturation and their activity is controlled by the presence of endogenous protease inhibitors.
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spelling pubmed-71309372020-04-08 Proteolysis and antigen presentation by MHC class II molecules Bryant, Paula Wolf Lennon-Duménil, Ana-Maria Fiebiger, Edda Lagaudriére-Gesbert, Cécile Ploegh, Hidde L Adv Immunol Article Proteolysis is the primary mechanism used by all cells not only to dispose of unwanted proteins but also to regulate protein function and maintain cellular homeostasis. Proteases that reside in the endocytic pathway are the principal actors of terminal protein degradation. The proteases contained in the endocytic pathway are classified into four major groups based on the active-site amino acid used by the enzyme to hydrolyze amide bonds of proteins: cysteine, aspartyl, serine, and metalloproteases. The presentation of peptide antigens by major histocompatibility complex (MHC) class II molecules is strictly dependent on the action of proteases. Class II molecules scour the endocytic pathway for antigenic peptides to bind and present at the cell surface for recognition by CD4(+) T cells. The specialized cell types that support antigen presentation by class II molecules are commonly referred to as professional antigen presenting cells (APCs), which include bone marrow-derived B lymphocytes, dendritic cells (DCs), and macrophages. In addition, the expression of certain endocytic proteases is regulated either at the level of gene transcription or enzyme maturation and their activity is controlled by the presence of endogenous protease inhibitors. Published by Elsevier Inc. 2002 2004-01-07 /pmc/articles/PMC7130937/ /pubmed/12078484 http://dx.doi.org/10.1016/S0065-2776(02)80013-X Text en Copyright © 2002 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bryant, Paula Wolf
Lennon-Duménil, Ana-Maria
Fiebiger, Edda
Lagaudriére-Gesbert, Cécile
Ploegh, Hidde L
Proteolysis and antigen presentation by MHC class II molecules
title Proteolysis and antigen presentation by MHC class II molecules
title_full Proteolysis and antigen presentation by MHC class II molecules
title_fullStr Proteolysis and antigen presentation by MHC class II molecules
title_full_unstemmed Proteolysis and antigen presentation by MHC class II molecules
title_short Proteolysis and antigen presentation by MHC class II molecules
title_sort proteolysis and antigen presentation by mhc class ii molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130937/
https://www.ncbi.nlm.nih.gov/pubmed/12078484
http://dx.doi.org/10.1016/S0065-2776(02)80013-X
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