Characterization of murine hepatitis virus (JHM) RNA from rats with experimental encephalomyelitis

When Wistar Furth rats are inoculated intracerebrally with the murine hepatitis virus JHM they often develop a demyelinating disease with resulting hind leg paralysis. Using an RNA transfer procedure and hybridization kinetic analysis, the virus-specific RNA in these rats was characterized. The patt...

Descripción completa

Detalles Bibliográficos
Autores principales: Jackson, Dennis P., Percy, Dean H., Morris, Vincent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1984
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131065/
https://www.ncbi.nlm.nih.gov/pubmed/6091331
http://dx.doi.org/10.1016/0042-6822(84)90221-6
Descripción
Sumario:When Wistar Furth rats are inoculated intracerebrally with the murine hepatitis virus JHM they often develop a demyelinating disease with resulting hind leg paralysis. Using an RNA transfer procedure and hybridization kinetic analysis, the virus-specific RNA in these rats was characterized. The pattern of JHM-specific RNA varied with individual infections of Wistar Furth rats. However, two species of JHM-specific RNA, the nucleocapsid and a 2.1–2.4 × 10(6)-Da RNA species were generally present. A general decrease in JHM-specific RNA in brains' and spinal cord samples taken later than 20 days postinoculation was observed; however, JHM-specific RNA persisted in the spinal cord longer than in the brain of these rats.

Ejemplares similares