Effects of intravenously infused Fluosol-DA 20% in rats()

Rats were injected with a fractionated 50 ml/kg dose of Fluosol®-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significan...

Descripción completa

Detalles Bibliográficos
Autores principales: West, Laurie, McIntosh, Norma, Gendler, Simona, Seymour, Christine, Wisdom, Charlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1986
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131096/
https://www.ncbi.nlm.nih.gov/pubmed/3759552
http://dx.doi.org/10.1016/0360-3016(86)90163-X
_version_ 1783517160701689856
author West, Laurie
McIntosh, Norma
Gendler, Simona
Seymour, Christine
Wisdom, Charlene
author_facet West, Laurie
McIntosh, Norma
Gendler, Simona
Seymour, Christine
Wisdom, Charlene
author_sort West, Laurie
collection PubMed
description Rats were injected with a fractionated 50 ml/kg dose of Fluosol®-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals.
format Online
Article
Text
id pubmed-7131096
institution National Center for Biotechnology Information
language English
publishDate 1986
publisher Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-71310962020-04-08 Effects of intravenously infused Fluosol-DA 20% in rats() West, Laurie McIntosh, Norma Gendler, Simona Seymour, Christine Wisdom, Charlene Int J Radiat Oncol Biol Phys Article Rats were injected with a fractionated 50 ml/kg dose of Fluosol®-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals. Published by Elsevier Inc. 1986-08 2009-12-16 /pmc/articles/PMC7131096/ /pubmed/3759552 http://dx.doi.org/10.1016/0360-3016(86)90163-X Text en Copyright © 1986 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
West, Laurie
McIntosh, Norma
Gendler, Simona
Seymour, Christine
Wisdom, Charlene
Effects of intravenously infused Fluosol-DA 20% in rats()
title Effects of intravenously infused Fluosol-DA 20% in rats()
title_full Effects of intravenously infused Fluosol-DA 20% in rats()
title_fullStr Effects of intravenously infused Fluosol-DA 20% in rats()
title_full_unstemmed Effects of intravenously infused Fluosol-DA 20% in rats()
title_short Effects of intravenously infused Fluosol-DA 20% in rats()
title_sort effects of intravenously infused fluosol-da 20% in rats()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131096/
https://www.ncbi.nlm.nih.gov/pubmed/3759552
http://dx.doi.org/10.1016/0360-3016(86)90163-X
work_keys_str_mv AT westlaurie effectsofintravenouslyinfusedfluosolda20inrats
AT mcintoshnorma effectsofintravenouslyinfusedfluosolda20inrats
AT gendlersimona effectsofintravenouslyinfusedfluosolda20inrats
AT seymourchristine effectsofintravenouslyinfusedfluosolda20inrats
AT wisdomcharlene effectsofintravenouslyinfusedfluosolda20inrats

Ejemplares similares