Cargando…
Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection
Dysfunction of subcortical serotoninergic neurons has been implicated in some behaviour disturbances. The serotoninergic neurons in the dorsal and median raphe project widely in the brain. They innervate the olfactory bulbs and can be targets for exogenous agents attacking the olfactory epithelium a...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
1990
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131220/ https://www.ncbi.nlm.nih.gov/pubmed/1696362 http://dx.doi.org/10.1016/0306-4522(90)90089-M |
_version_ | 1783517189068816384 |
---|---|
author | Mohammed, A.K. Magnusson, O. Maehlen, J. Fonnum, F Norrby, E. Schultzberg, M. Kristensson, K. |
author_facet | Mohammed, A.K. Magnusson, O. Maehlen, J. Fonnum, F Norrby, E. Schultzberg, M. Kristensson, K. |
author_sort | Mohammed, A.K. |
collection | PubMed |
description | Dysfunction of subcortical serotoninergic neurons has been implicated in some behaviour disturbances. The serotoninergic neurons in the dorsal and median raphe project widely in the brain. They innervate the olfactory bulbs and can be targets for exogenous agents attacking the olfactory epithelium and bulbs. We report here an injury to the serotoninergic neurons after intranasal infection in 12-day-old rats with a temperature-sensitive mutant of vesicular stomatitis virus. The brain infection was focal and transient. Viral antigens could no longer be detected 13–15 days after infection. In spite of this the animals, as adults, had a severe serotonin depletion in the cerebral cortex and hippocampus, and showed abnormal locomotor and explorative behaviour as well as learning deficits. The neocortex was histologically intact and parameters related to other neurotransmitters such as dopamine, noradrenaline, GABA and acetylcholine showed no marked changes. A relatively selective damage to serotoninergic nuclei as a result of virus neuroinvasion through a natural portal of entry, may constitute a new pathogenetic mechanism for cortical dysfunction and behavioural deficits. |
format | Online Article Text |
id | pubmed-7131220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71312202020-04-08 Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection Mohammed, A.K. Magnusson, O. Maehlen, J. Fonnum, F Norrby, E. Schultzberg, M. Kristensson, K. Neuroscience Article Dysfunction of subcortical serotoninergic neurons has been implicated in some behaviour disturbances. The serotoninergic neurons in the dorsal and median raphe project widely in the brain. They innervate the olfactory bulbs and can be targets for exogenous agents attacking the olfactory epithelium and bulbs. We report here an injury to the serotoninergic neurons after intranasal infection in 12-day-old rats with a temperature-sensitive mutant of vesicular stomatitis virus. The brain infection was focal and transient. Viral antigens could no longer be detected 13–15 days after infection. In spite of this the animals, as adults, had a severe serotonin depletion in the cerebral cortex and hippocampus, and showed abnormal locomotor and explorative behaviour as well as learning deficits. The neocortex was histologically intact and parameters related to other neurotransmitters such as dopamine, noradrenaline, GABA and acetylcholine showed no marked changes. A relatively selective damage to serotoninergic nuclei as a result of virus neuroinvasion through a natural portal of entry, may constitute a new pathogenetic mechanism for cortical dysfunction and behavioural deficits. Published by Elsevier Ltd. 1990 2003-03-17 /pmc/articles/PMC7131220/ /pubmed/1696362 http://dx.doi.org/10.1016/0306-4522(90)90089-M Text en Copyright © 1990 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Mohammed, A.K. Magnusson, O. Maehlen, J. Fonnum, F Norrby, E. Schultzberg, M. Kristensson, K. Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title | Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title_full | Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title_fullStr | Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title_full_unstemmed | Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title_short | Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
title_sort | behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131220/ https://www.ncbi.nlm.nih.gov/pubmed/1696362 http://dx.doi.org/10.1016/0306-4522(90)90089-M |
work_keys_str_mv | AT mohammedak behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT magnussono behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT maehlenj behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT fonnumf behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT norrbye behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT schultzbergm behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection AT kristenssonk behaviouraldeficitsandserotonindepletioninadultratsaftertransientinfantnasalviralinfection |