Entrada del virus de la inmunodeficiencia humana en las células: mecanismos y posibilidades terapéuticas

Human immunodeficiency virus (HIV) entry into cells is the first step in the viral replication cycle; which has been explored as a new therapeutic target; A better knowledge of the mechanisms involved in the entry process has led to the development of agents; which may inhibit each of the different steps of the viral entry process: attachment of the gp120 to the CD4 cell receptor; binding of the gp120 to CCR5 or CXCR4 coreceptors; and the fusion of viral and cell membranes; Entry inhibitors are the latest family of antiretroviral compounds; being enfuvirtide; a fusion inhibitor; the first approved; Several other entry inhibitors are currently in clinical development and hopefully soon will be part of the therapeutic armamentarium against HIV