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Vaccine-induced enhancement of viral infections

Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine devel...

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Autores principales: Huisman, W., Martina, B.E.E., Rimmelzwaan, G.F., Gruters, R.A., Osterhaus, A.D.M.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131326/
https://www.ncbi.nlm.nih.gov/pubmed/19022319
http://dx.doi.org/10.1016/j.vaccine.2008.10.087
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author Huisman, W.
Martina, B.E.E.
Rimmelzwaan, G.F.
Gruters, R.A.
Osterhaus, A.D.M.E.
author_facet Huisman, W.
Martina, B.E.E.
Rimmelzwaan, G.F.
Gruters, R.A.
Osterhaus, A.D.M.E.
author_sort Huisman, W.
collection PubMed
description Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.
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spelling pubmed-71313262020-04-08 Vaccine-induced enhancement of viral infections Huisman, W. Martina, B.E.E. Rimmelzwaan, G.F. Gruters, R.A. Osterhaus, A.D.M.E. Vaccine Article Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis. Elsevier Ltd. 2009-01-22 2008-11-18 /pmc/articles/PMC7131326/ /pubmed/19022319 http://dx.doi.org/10.1016/j.vaccine.2008.10.087 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Huisman, W.
Martina, B.E.E.
Rimmelzwaan, G.F.
Gruters, R.A.
Osterhaus, A.D.M.E.
Vaccine-induced enhancement of viral infections
title Vaccine-induced enhancement of viral infections
title_full Vaccine-induced enhancement of viral infections
title_fullStr Vaccine-induced enhancement of viral infections
title_full_unstemmed Vaccine-induced enhancement of viral infections
title_short Vaccine-induced enhancement of viral infections
title_sort vaccine-induced enhancement of viral infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131326/
https://www.ncbi.nlm.nih.gov/pubmed/19022319
http://dx.doi.org/10.1016/j.vaccine.2008.10.087
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