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Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs

Four viruses were compared for their ability to induce an intestinal antibody response in piglets. Antibodies were not detected in response to oral vaccination with either fowlpox virus or a baculovirus (BV). Simultaneous oral dosing and parenteral inoculation with high concentrations of BV in an oi...

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Detalles Bibliográficos
Autores principales: Tuboly, T., Nagy, É., Derbyshire, J.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131402/
https://www.ncbi.nlm.nih.gov/pubmed/8393209
http://dx.doi.org/10.1016/0034-5288(93)90133-Z
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author Tuboly, T.
Nagy, É.
Derbyshire, J.B.
author_facet Tuboly, T.
Nagy, É.
Derbyshire, J.B.
author_sort Tuboly, T.
collection PubMed
description Four viruses were compared for their ability to induce an intestinal antibody response in piglets. Antibodies were not detected in response to oral vaccination with either fowlpox virus or a baculovirus (BV). Simultaneous oral dosing and parenteral inoculation with high concentrations of BV in an oil emulsion adjuvant induced high levels of circulating virus neutralising (VN) antibodies, and also low levels of intestinal antibodies when booster doses of virus were given. In response to oral vaccination with swinepox virus (SPV), low levels of circulating and intestinal VN antibodies, and higher titres of antibodies reactive in an enzyme immunoassay, including intestinal antibodies of the IgA class, were detected. Oral vaccination with porcine adenovirus type 3 (PAV-3) stimulated both circulating and intestinal VN antibodies, and IgA antibodies were demonstrated in the intestinal contents. It was concluded that SPV and PAV-3 might be suitable vectors for the expression of genes encoding the protective antigens of porcine enteric viruses.
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spelling pubmed-71314022020-04-08 Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs Tuboly, T. Nagy, É. Derbyshire, J.B. Res Vet Sci Article Four viruses were compared for their ability to induce an intestinal antibody response in piglets. Antibodies were not detected in response to oral vaccination with either fowlpox virus or a baculovirus (BV). Simultaneous oral dosing and parenteral inoculation with high concentrations of BV in an oil emulsion adjuvant induced high levels of circulating virus neutralising (VN) antibodies, and also low levels of intestinal antibodies when booster doses of virus were given. In response to oral vaccination with swinepox virus (SPV), low levels of circulating and intestinal VN antibodies, and higher titres of antibodies reactive in an enzyme immunoassay, including intestinal antibodies of the IgA class, were detected. Oral vaccination with porcine adenovirus type 3 (PAV-3) stimulated both circulating and intestinal VN antibodies, and IgA antibodies were demonstrated in the intestinal contents. It was concluded that SPV and PAV-3 might be suitable vectors for the expression of genes encoding the protective antigens of porcine enteric viruses. Published by Elsevier Ltd. 1993-05 2011-01-21 /pmc/articles/PMC7131402/ /pubmed/8393209 http://dx.doi.org/10.1016/0034-5288(93)90133-Z Text en Copyright © 1993 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tuboly, T.
Nagy, É.
Derbyshire, J.B.
Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title_full Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title_fullStr Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title_full_unstemmed Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title_short Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
title_sort potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131402/
https://www.ncbi.nlm.nih.gov/pubmed/8393209
http://dx.doi.org/10.1016/0034-5288(93)90133-Z
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