Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()

The replication of the murine coronaviruses MHV(3) and JHM has been studied in somatic cell hybrids formed between murine fibroblast L2 cells which support lytic infections with both these agents, and rat RN2 Schwannoma cells which support the replication of JHM in a temperature-sensitive, persisten...

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Detalles Bibliográficos
Autor principal: Flintoff, Wayne F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1984
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131418/
https://www.ncbi.nlm.nih.gov/pubmed/6100577
http://dx.doi.org/10.1016/0042-6822(84)90312-X
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author Flintoff, Wayne F.
author_facet Flintoff, Wayne F.
author_sort Flintoff, Wayne F.
collection PubMed
description The replication of the murine coronaviruses MHV(3) and JHM has been studied in somatic cell hybrids formed between murine fibroblast L2 cells which support lytic infections with both these agents, and rat RN2 Schwannoma cells which support the replication of JHM in a temperature-sensitive, persistent manner but are restrictive to the replication of MHV(3). The results described in this report indicate that the totally permissive state is dominant over the persistent or restricted state since the hybrid cells permit the replication of both these viral agents in a lytic manner.
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spelling pubmed-71314182020-04-08 Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells() Flintoff, Wayne F. Virology Article The replication of the murine coronaviruses MHV(3) and JHM has been studied in somatic cell hybrids formed between murine fibroblast L2 cells which support lytic infections with both these agents, and rat RN2 Schwannoma cells which support the replication of JHM in a temperature-sensitive, persistent manner but are restrictive to the replication of MHV(3). The results described in this report indicate that the totally permissive state is dominant over the persistent or restricted state since the hybrid cells permit the replication of both these viral agents in a lytic manner. Published by Elsevier Inc. 1984-04-30 2004-02-06 /pmc/articles/PMC7131418/ /pubmed/6100577 http://dx.doi.org/10.1016/0042-6822(84)90312-X Text en Copyright © 1984 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Flintoff, Wayne F.
Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title_full Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title_fullStr Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title_full_unstemmed Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title_short Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat Schwannoma cells()
title_sort replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat schwannoma cells()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131418/
https://www.ncbi.nlm.nih.gov/pubmed/6100577
http://dx.doi.org/10.1016/0042-6822(84)90312-X
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