Cargando…

Processing of the Coronavirus MHV-JHM Polymerase Polyprotein: Identification of Precursors and Proteolytic Products Spanning 400 Kilodaltons of ORF1a()

The replicase of mouse hepatitis virus strain JHM (MHV-JHM) is encoded by two overlapping open reading frames, ORF1a and ORF1b, which are translated to produce a 750-kDa precursor polyprotein. The polyprotein is proposed to be processed by viral proteinases to generate the functional replicase compl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schiller, Jennifer J., Kanjanahaluethai, Amornrat, Baker, Susan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press. 1998
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131687/ https://www.ncbi.nlm.nih.gov/pubmed/9514967 http://dx.doi.org/10.1006/viro.1997.9010

Ejemplares similares

Identification of the polymerase polyprotein products p72 and p65 of the murine coronavirus MHV-JHM
por: Gao, Hong-Qiang, et al.
Publicado: (1996)

MHV-JHM infection in immortalized murine oligodendrocytes()
por: Gilmore, W., et al.
Publicado: (1994)

The virus-specific intracellular RNA species of two murine coronaviruses: MHV-A59 and MHV-JHM()
por: Leibowitz, Julian L., et al.
Publicado: (1981)

Coronavirus MHV-JHM: nucleotide sequence of the mRNA that encodes the membrane protein.
por: Pfleiderer, M, et al.
Publicado: (1986)

The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM
por: Smith, Abigail L., et al.
Publicado: (1991)

Biological and macromolecular properties of murine cells persistently infected with MHV-JHM
por: Leibowitz, J. L., et al.
Publicado: (1984)

β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM
por: Gilmore, Wendy, et al.
Publicado: (1993)

Antigenic relationships of murine coronaviruses: Analysis using monoclonal antibodies to JHM (MHV-4) virus
por: Fleming, John O., et al.
Publicado: (1983)

Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated
por: Wang, Fun-In, et al.
Publicado: (1990)

Experimental demyelination induced by coronavirus JHM (MHV-4): molecular identification of a viral determinant of paralytic disease()
por: Fleming, J.O., et al.
Publicado: (1987)

Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody()
por: Perlman, S., et al.
Publicado: (1987)

Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events
por: Denison, Mark R., et al.
Publicado: (1992)

The ns 4 gene of mouse hepatitis virus (MHV), strain A 59 contains two ORFs and thus differs from ns 4 of the JHM and S strains
por: Weiss, Susan R., et al.
Publicado: (1993)

A Conserved Biogenesis Pathway for Nucleoporins: Proteolytic Processing of a 186-Kilodalton Precursor Generates Nup98 and the Novel Nucleoporin, Nup96
por: Fontoura, Beatriz M.A., et al.
Publicado: (1999)

Interleukin-6 induction in vitro in mouse brain endothelial cells and astrocytes by exposure to mouse hepatitis virus (MHV-4, JHM)
por: Joseph, Jeymohan, et al.
Publicado: (1993)

Membrane topology of murine coronavirus replicase nonstructural protein 3
por: Kanjanahaluethai, Amornrat, et al.
Publicado: (2007)

Identification and Characterization of a 65-kDa Protein Processed from the Gene 1 Polyprotein of the Murine Coronavirus MHV-A59
por: Denison, Mark R., et al.
Publicado: (1995)

Mouse Hepatitis Virus Strain A59 RNA Polymerase Gene ORF 1a: Heterogeneity among MHV Strains
por: Bonilla, Pedro J., et al.
Publicado: (1994)

Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein
por: Sehgal, Deepak, et al.
Publicado: (2006)

Characterisation and Mutational Analysis of an ORF 1a-Encoding Proteinase Domain Responsible for Proteolytic Processing of the Infectious Bronchitis Virus 1a/1b Polyprotein
por: Liu, D.X., et al.
Publicado: (1995)

Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles
por: Clementz, Mark A., et al.
Publicado: (2008)

Viral precursor polyproteins: keys of regulation from replication to maturation
por: Yost, Samantha A, et al.
Publicado: (2013)

Duration of challenge immunity to coronavirus JHM in mice
por: Barthold, S. W., et al.
Publicado: (1989)

Acquired Fusion Activity of a Murine Coronavirus MHV-2 Variant with Mutations in the Proteolytic Cleavage Site and the Signal Sequence of the S Protein()
por: YAMADA, YASUKO K., et al.
Publicado: (1997)

ORF6 and ORF61 Expressing MVA Vaccines Impair Early but Not Late Latency in Murine Gammaherpesvirus MHV-68 Infection
por: Samreen, Baila, et al.
Publicado: (2019)

Mouse hepatitis virus (MHV-4, JHM) blocks γ-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells
por: Joseph, Jeymohan, et al.
Publicado: (1991)

Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection
por: Grzybicki, Dana M, et al.
Publicado: (1997)

Physiochemical Characterization and Domain Annotation of ORF1ab Polyprotein of Novel Corona Virus 19
por: Kumar, Amit, et al.
Publicado: (2020)

Co-folding and RNA activation of poliovirus 3C(pro) polyprotein precursors
por: Campagnola, Grace, et al.
Publicado: (2023)

Evolution of Mouse Hepatitis Virus (MHV) during Chronic Infection: Quasispecies Nature of the Persisting MHV RNA
por: Adami, Cecilia, et al.
Publicado: (1995)

Role of the Replicase Gene of Murine Coronavirus JHM Strain in Hepatitis
por: Navas-Martín, Sonia, et al.
Publicado: (2006)

Molecular Determinants of Coronavirus Mhv- Induced Demyelination
por: Fu, Li, et al.
Publicado: (2005)

Coronavirus MHV-3-Induced Apoptosis in Macrophages
por: Belyavsky, Michail, et al.
Publicado: (1998)

Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus
por: Wahaab, Abdul, et al.
Publicado: (2021)

The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection
por: Leang, Ronika Sitapara, et al.
Publicado: (2011)

MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication
por: Deming, Damon J., et al.
Publicado: (2006)

MHV nucleocapsid synthesis in the presence of cycloheximide and accumulation of negative strand MHV RNA
por: Perlman, Stanley, et al.
Publicado: (1986)

A Modular Hepatitis E Virus Replicon System for Studies on the Role of ORF1-Encoded Polyprotein Domains
por: Cierniak, Filip, et al.
Publicado: (2022)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

Coronavirus JHM: nucleotide sequence of the mRNA that encodes nucleocapsid protein.
por: Skinner, M A, et al.
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_mnp2ig74kl2pa3788pov1q7oab