Cell receptor-independent infection by a neurotropic murine coronavirus

The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to pr...

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Detalles Bibliográficos
Autores principales: Gallagher, Thomas M., Buchmeier, Michael J., Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1992
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131763/
https://www.ncbi.nlm.nih.gov/pubmed/1413526
http://dx.doi.org/10.1016/0042-6822(92)90223-C
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author Gallagher, Thomas M.
Buchmeier, Michael J.
Perlman, Stanley
author_facet Gallagher, Thomas M.
Buchmeier, Michael J.
Perlman, Stanley
author_sort Gallagher, Thomas M.
collection PubMed
description The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.
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spelling pubmed-71317632020-04-08 Cell receptor-independent infection by a neurotropic murine coronavirus Gallagher, Thomas M. Buchmeier, Michael J. Perlman, Stanley Virology Short Communication The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts. Published by Elsevier Inc. 1992-11 2004-02-11 /pmc/articles/PMC7131763/ /pubmed/1413526 http://dx.doi.org/10.1016/0042-6822(92)90223-C Text en Copyright © 1992 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Gallagher, Thomas M.
Buchmeier, Michael J.
Perlman, Stanley
Cell receptor-independent infection by a neurotropic murine coronavirus
title Cell receptor-independent infection by a neurotropic murine coronavirus
title_full Cell receptor-independent infection by a neurotropic murine coronavirus
title_fullStr Cell receptor-independent infection by a neurotropic murine coronavirus
title_full_unstemmed Cell receptor-independent infection by a neurotropic murine coronavirus
title_short Cell receptor-independent infection by a neurotropic murine coronavirus
title_sort cell receptor-independent infection by a neurotropic murine coronavirus
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131763/
https://www.ncbi.nlm.nih.gov/pubmed/1413526
http://dx.doi.org/10.1016/0042-6822(92)90223-C
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