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Murine Coronavirus Spike Glycoprotein Mediates Degree of Viral Spread, Inflammation, and Virus-Induced Immunopathology in the Central Nervous System

The mouse hepatitis virus (MHV) spike glycoprotein is a major determinant of neurovirulence. We investigated how alterations in spike affect neurovirulence using two isogenic recombinant viruses differing exclusively in spike. S(4)R, containing the MHV-4 spike gene, is dramatically more neurovirulen...

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Detalles Bibliográficos
Autores principales:	Phillips, Joanna J., Chua, Ming Ming, Rall, Glenn F., Weiss, Susan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science (USA). 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131834/ https://www.ncbi.nlm.nih.gov/pubmed/12359451 http://dx.doi.org/10.1006/viro.2002.1551

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