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LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11

Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated tha...

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Autores principales: Wu, Haixia, Dai, Yuedi, Zhang, Dexiang, Zhang, Xiaoyu, He, Zhiyun, Xie, Xiaojun, Cai, Chudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131851/
https://www.ncbi.nlm.nih.gov/pubmed/32045135
http://dx.doi.org/10.1002/cam4.2850
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author Wu, Haixia
Dai, Yuedi
Zhang, Dexiang
Zhang, Xiaoyu
He, Zhiyun
Xie, Xiaojun
Cai, Chudong
author_facet Wu, Haixia
Dai, Yuedi
Zhang, Dexiang
Zhang, Xiaoyu
He, Zhiyun
Xie, Xiaojun
Cai, Chudong
author_sort Wu, Haixia
collection PubMed
description Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR‐223‐3p in colon cancer cells. SOX11 was confirmed as a target gene of miR‐223‐3p. The effect of miR‐223‐3p on colon cancer cells was then investigated. MiR‐223‐3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer cells was studied. SOX11 overexpression inhibited the invasion of colon cancer cells. LINC00961 acted as an anti‐oncogene and upregulated SOX11 expression by functioning as a miR‐223‐3p sponge. This research revealed the molecular mechanism of LINC00961 in colon cancer. LINC00961 might act as a potential diagnostic biomarker and therapeutic target for further clinical treatments.
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spelling pubmed-71318512020-04-06 LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11 Wu, Haixia Dai, Yuedi Zhang, Dexiang Zhang, Xiaoyu He, Zhiyun Xie, Xiaojun Cai, Chudong Cancer Med Cancer Biology Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR‐223‐3p in colon cancer cells. SOX11 was confirmed as a target gene of miR‐223‐3p. The effect of miR‐223‐3p on colon cancer cells was then investigated. MiR‐223‐3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer cells was studied. SOX11 overexpression inhibited the invasion of colon cancer cells. LINC00961 acted as an anti‐oncogene and upregulated SOX11 expression by functioning as a miR‐223‐3p sponge. This research revealed the molecular mechanism of LINC00961 in colon cancer. LINC00961 might act as a potential diagnostic biomarker and therapeutic target for further clinical treatments. John Wiley and Sons Inc. 2020-02-11 /pmc/articles/PMC7131851/ /pubmed/32045135 http://dx.doi.org/10.1002/cam4.2850 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Wu, Haixia
Dai, Yuedi
Zhang, Dexiang
Zhang, Xiaoyu
He, Zhiyun
Xie, Xiaojun
Cai, Chudong
LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title_full LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title_fullStr LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title_full_unstemmed LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title_short LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11
title_sort linc00961 inhibits the migration and invasion of colon cancer cells by sponging mir‐223‐3p and targeting sox11
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131851/
https://www.ncbi.nlm.nih.gov/pubmed/32045135
http://dx.doi.org/10.1002/cam4.2850
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