Specialized medial prefrontal-amygdala coordination in other-regarding decision preference

Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain network interact during social decision-making. Here, we investigated oscillatory neuronal interactions between the basolateral amygdala and the rostral anterior cingulate gyrus of the medial prefrontal cortex while monkeys expressed context-dependent positive or negative other-regarding preference (ORP), where decisions impacted the reward received by another monkey. Synchronization between the two nodes was enhanced for positive ORP, but suppressed for negative ORP. These interactions occurred in beta and gamma frequency bands depending on the area contributing spikes, exhibited a specific directionality of information flow associated with positive ORP, and could be used to decode social decisions. These findings suggest that specialized coordination in the medial prefrontal-amygdala network underlies social-decision preference.