Cargando…

The marine‐derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα

Recent studies have demonstrated that commercially available lipid‐lowering drugs cause various side effects; therefore, searching for anti‐hyperlipidaemic compounds with lower toxicity is a research hotspot. This study was designed to investigate whether the marine‐derived compound, 5‐hydroxy‐3‐met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ting, Hu, Shu‐Mei, Pang, Xiao‐Yan, Wang, Jun‐feng, Yin, Jia‐Yu, Li, Fa‐Hui, Wang, Jin, Yang, Xiao‐Qian, Xia, Bin, Liu, Yong‐Hong, Song, Wei‐Guo, Guo, Shou‐Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131916/ https://www.ncbi.nlm.nih.gov/pubmed/31981312 http://dx.doi.org/10.1111/jcmm.15012

Ejemplares similares

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα
por: Goldwasser, Jonathan, et al.
Publicado: (2010)

Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway
por: Zhang, Zepeng, et al.
Publicado: (2020)

Bilirubin Binding to PPARα Inhibits Lipid Accumulation
por: Stec, David E., et al.
Publicado: (2016)

Role of Intestinal LXRα in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation
por: Benítez-Santana, Tibiábin, et al.
Publicado: (2017)

Sex-Related Differences of Lipid Metabolism Induced by Triptolide: The Possible Role of the LXRα/SREBP-1 Signaling Pathway
por: Jiang, Zhenzhou, et al.
Publicado: (2016)

Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages
por: Watanabe, Yuichiro, et al.
Publicado: (2003)

Sini Decoction Intervention on Atherosclerosis via PPARγ-LXRα-ABCA1 Pathway in Rabbits
por: Ju, Shicong, et al.
Publicado: (2018)

Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels
por: Zhou, Yun-Fei, et al.
Publicado: (2014)

RXRα is Upregulated in First Trimester Endometrial Glands of Spontaneous Abortions Unlike LXR and PPARγ
por: Knabl, J., et al.
Publicado: (2016)

LXRα and LXRβ Nuclear Receptors Evolved in the Common Ancestor of Gnathostomes
por: Fonseca, Elza, et al.
Publicado: (2017)

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia
por: Zhang, Tao, et al.
Publicado: (2019)

Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells
por: Lin, Xiao-Long, et al.
Publicado: (2017)

Benzyl Furanones and Pyrones from the Marine-Derived Fungus Aspergillus terreus Induced by Chemical Epigenetic Modification
por: Wu, Jing-Shuai, et al.
Publicado: (2020)

Foam Cell Specific LXRα Ligand
por: Feldmann, Radmila, et al.
Publicado: (2013)

Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells
por: Mahankali, Madhu, et al.
Publicado: (2015)

Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1
por: Jia, Qingling, et al.
Publicado: (2019)

Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches
por: Chen, Meimei, et al.
Publicado: (2018)

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
por: Hellemans, Karine H., et al.
Publicado: (2009)

Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway
por: Franceschelli, Sara, et al.
Publicado: (2023)

Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma
por: Xie, Yang, et al.
Publicado: (2022)

Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1
por: Zhang, Xiaonan, et al.
Publicado: (2019)

Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARδ
por: Shou, Jia-Wen, et al.
Publicado: (2023)

Knockdown of LXRα Inhibits Goat Intramuscular Preadipocyte Differentiation
por: Xiong, Yan, et al.
Publicado: (2018)

PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
por: Gu, Shu-Jun, et al.
Publicado: (2014)

Regulation of type 1 iodothyronine deiodinase by LXRα
por: Sakane, Yoriko, et al.
Publicado: (2017)

miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
por: Vinod, Manjula, et al.
Publicado: (2014)

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma
por: Wang, KeShan, et al.
Publicado: (2019)

Lipid Regulators during Atherogenesis: Expression of LXR, PPAR, and SREBP mRNA in the Human Aorta
por: Shchelkunova, Tatyana A., et al.
Publicado: (2013)

The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD
por: Dixon, Emmanuel D., et al.
Publicado: (2021)

PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
por: Majdalawieh, Amin, et al.
Publicado: (2010)

Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis
por: Wang, Peng, et al.
Publicado: (2021)

Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway
por: Gao, Pan, et al.
Publicado: (2022)

The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis
por: Xu, Pengfei, et al.
Publicado: (2018)

HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD
por: Agarwal, Neeti, et al.
Publicado: (2017)

Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(−/−) Mice Fed a High-Fat/High-Cholesterol Diet
por: Hu, Yan-Wei, et al.
Publicado: (2013)

Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque
por: Wang, Huan, et al.
Publicado: (2018)

Cholesterol efflux is LXRα isoform-dependent in human macrophages
por: Ma, A Zhi Sha, et al.
Publicado: (2014)

2290: Control of atherosclerosis regression by LXRα S198 phosphorylation
por: Shrestha, Elina, et al.
Publicado: (2018)

Effects of A 4-Week Aerobic Exercise on Lipid Profile and Expression of LXRα in Rat Liver
por: Kazeminasab, Fatemeh, et al.
Publicado: (2017)

Crocin ameliorates atherosclerosis by promoting the reverse cholesterol transport and inhibiting the foam cell formation via regulating PPARγ/LXR-α
por: Zhang, Feng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mido01dh8ro9kugusm8so9r5nh