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Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer
Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RN...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131947/ https://www.ncbi.nlm.nih.gov/pubmed/32048814 http://dx.doi.org/10.1111/jcmm.15054 |
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author | Fang, Cheng Wang, Lixin Gong, Chenyuan Wu, Wenbin Yao, Chao Zhu, Shiguo |
author_facet | Fang, Cheng Wang, Lixin Gong, Chenyuan Wu, Wenbin Yao, Chao Zhu, Shiguo |
author_sort | Fang, Cheng |
collection | PubMed |
description | Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs. |
format | Online Article Text |
id | pubmed-7131947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71319472020-04-06 Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer Fang, Cheng Wang, Lixin Gong, Chenyuan Wu, Wenbin Yao, Chao Zhu, Shiguo J Cell Mol Med Reviews Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs. John Wiley and Sons Inc. 2020-02-12 2020-03 /pmc/articles/PMC7131947/ /pubmed/32048814 http://dx.doi.org/10.1111/jcmm.15054 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Fang, Cheng Wang, Lixin Gong, Chenyuan Wu, Wenbin Yao, Chao Zhu, Shiguo Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title | Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title_full | Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title_fullStr | Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title_full_unstemmed | Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title_short | Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer |
title_sort | long non‐coding rnas: how to regulate the metastasis of non–small‐cell lung cancer |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131947/ https://www.ncbi.nlm.nih.gov/pubmed/32048814 http://dx.doi.org/10.1111/jcmm.15054 |
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