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Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s

DNA methyltransferase 1 (DNMT1), a large multidomain enzyme, is believed to be involved in the passive transmission of genomic methylation patterns via methylation maintenance. Yet, the molecular mechanism of interaction networks underlying DNMT1 structures, dynamics, and its biological significance...

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Detalles Bibliográficos
Autores principales:	Liang, Zhongjie, Zhu, Yu, Long, Jie, Ye, Fei, Hu, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132064/ https://www.ncbi.nlm.nih.gov/pubmed/32280430 http://dx.doi.org/10.1016/j.csbj.2020.03.016

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