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Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase

All known polymerases copy genetic material by catalyzing phosphodiester bond formation. This highly conserved activity proceeds by a common mechanism, such that incorporated nucleoside analogs terminate chain elongation if the resulting primer strand lacks a terminal hydroxyl group. Even conservati...

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Detalles Bibliográficos
Autores principales:	Lelyveld, Victor S., Zhang, Wen, Szostak, Jack W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132125/ https://www.ncbi.nlm.nih.gov/pubmed/32188786 http://dx.doi.org/10.1073/pnas.1922400117

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